Evidence behind use of orthovolt intraoperative radiotherapy and other techniques of IORT in recurrent colorectal cancer treatment

There are only scarce literature data on the use of with orthovolt intraoperative radiotherapy (IORT) in treatment of colorectal cancer recurrence. Previous experience with IORT using lowenergy photons highlights the need for better strategies of combined therapy in referral centres where multidisciplinary treatment options are widely available. There is an absolute need for large randomized studies that will clearly assess the value of different treatment options in colorectal cancer (CRC) recurrences, and thus create uniform rules to be observed in this disease.