A different mode of entry by dengue-2 neutralisation escape mutant virus

被引：34
|
作者：
Lim, HY [1 ]
Ng, ML [1 ]
机构：
[1] Natl Univ Singapore, Dept Microbiol, Singapore 119260, Singapore
来源：
ARCHIVES OF VIROLOGY | 1999年 / 144卷 / 05期
关键词：
D O I：
10.1007/s007050050561
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Entry processes were compared between dengue-2 (DEN-2) virus and a DEN-2 neutralisation escape mutant virus in baby hamster kidney (BHK) cells. The mutant virus (mu6B2) was resistant to neutralisation by a monoclonal antibody, MAb 6B2. Infection of BHK cells by the wild-type DEN-2 virus resulted in direct penetration of the virions into the cytoplasm whereas the mutant virus entered cells by endocytosis. The continual presence of the monoclonal antibody might have asserted some pressure for the mutant to adopt a different mode of entry.
引用
收藏
页码：989 / 995
页数：7
相关论文
共 50 条
  • [1] A different mode of entry by dengue-2 neutralisation escape mutant virus
    H. Y. Lim
    M. L. Ng
    Archives of Virology, 1999, 144 : 989 - 995
  • [2] Alteration of virus entry mode: A neutralisation mechanism for dengue-2 virus
    Se-Thoe, SY
    Ling, AE
    Ng, MML
    JOURNAL OF MEDICAL VIROLOGY, 2000, 62 (03) : 364 - 376
  • [3] DENGUE-2 VIRUS IN KENYA
    JOHNSON, BK
    OKOTH, F
    TUKEI, PM
    MUGAMBI, M
    WOODY, JN
    MORRILL, JC
    HYAMS, KC
    LANCET, 1990, 336 (8722): : 1071 - 1071
  • [4] DENGUE-2 VIRUS IN KENYA
    JOHNSON, BK
    MUSOKE, S
    OCHENG, D
    GICHOGO, A
    REES, PH
    LANCET, 1982, 2 (8291): : 208 - 209
  • [5] Failure of dengue-2 virus antibody to interfere with the isolation of dengue-2 virus from Aedes aegypti (Diptera: Culicidae)
    Weng, MH
    Shaio, MF
    Yao, CW
    JOURNAL OF MEDICAL ENTOMOLOGY, 2000, 37 (04) : 641 - 644
  • [6] PROTECTION OF MICE AGAINST DENGUE-2 VIRUS ENCEPHALITIS BY IMMUNIZATION WITH THE DENGUE-2 VIRUS NONSTRUCTURAL GLYCOPROTEIN NS1
    SCHLESINGER, JJ
    BRANDRISS, MW
    WALSH, EE
    JOURNAL OF GENERAL VIROLOGY, 1987, 68 : 853 - 857
  • [7] Amino acid and phenotypic changes in dengue 2 virus associated with escape from neutralisation by IgM antibody
    Lok, SM
    Ng, ML
    Aaskov, J
    JOURNAL OF MEDICAL VIROLOGY, 2001, 65 (02) : 315 - 323
  • [8] STRUCTURAL-ANALYSIS OF DENGUE-2 VIRUS GENOME
    KALYAN, N
    NOHARA, M
    HENCHAL, EA
    PADMANABHAN, RK
    FEDERATION PROCEEDINGS, 1983, 42 (07) : 1972 - 1972
  • [9] Dengue-2 virus infection of human bone marrow: Characterization of dengue-2 antigen-positive stromal cells
    Rothwell, SW
    Putnak, R
    LaRussa, VF
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1996, 54 (05): : 503 - 510
  • [10] Prevalence of dengue-2 virus in nearby Caribbean islands
    Munoz-Jordan, Jorge L.
    Hunsperger, Elizabeth
    Beatty, Mark
    Clark, Gary
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2005, 73 (06): : 242 - 242
12345