The information security acts as the core for guaranteeing the smooth implementation of e-government affairs, which is respectively determined by the characteristics of the "government" and "electronic". When the the e-government goes further, the cloud computing can not only co-establish and share the information resources of the e-government, reducing the cost of inputs, but also impose both positive and negative influence on the information security. On the one hand, cloud computing enables the management of the information security to shift to centralization from decentralization, which is conducive to improve the security of e-government information; on the other hand, its unprecedented openness and complexity have also brought risks of the information security to the e-government affairs that can not be ignored. The construction of the information security system of cloud computing of the e-government affairs mainly includes technology, management and law.