Solvent-free synthesis of novel steroidal 2-aminopyridines

被引：11
|
作者：
Zhang, Yan-Ling [1 ,2 ,3 ]
Li, Ya-Fei [1 ,2 ]
Shi, Xiao-Li [1 ,2 ]
Yu, Bin [1 ,2 ]
Shi, Yun-Kai [1 ,2 ]
Liu, Hong-Min [1 ,2 ]
机构：
[1] Zhengzhou Univ, Sch Pharmaceut Sci, 100 KeXue DaDao, Zhengzhou 450001, Henan Province, Peoples R China
[2] Collaborat Innovat Ctr New Drug Res & Safety Eval, 100 KeXue DaDao, Zhengzhou 450001, Henan Province, Peoples R China
[3] Xuchang Univ, Coll Chem & Chem Engn, Xuchang 461000, Henan Province, Peoples R China
来源：
STEROIDS | 2016年 / 115卷
关键词：
Solvent-free; Steroidal pyridines; Synthesis; Enaminonitrile; PROSTATE-CANCER; DERIVATIVES; EFFICIENT; AGENTS; 3-CYANO-2-AMINOPYRIDINES; SPIROOXINDOLES; ABIRATERONE; GALETERONE; DIENAMIDES; INHIBITORS;
D O I：
10.1016/j.steroids.2016.09.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis of novel steroidal 3-cyano-2-aminopyridines using enaminonitrile and various primary amines was established under solvent-free condition. Structures of the new compounds were characterized by MS,H-1 and C-13 NMR data and the structure of 2-aminopyridine of the product 5b was further confirmed by X-ray analysis. The reaction mechanism was proposed on the basis of the key intermediate obtained. The adjacent amine and nitrile groups existed in the final products have the potential for late stage functionalization, which would provide efficient access to steroidal compound collections with structural diversity and complexity. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：147 / 153
页数：7
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