An injectable drug-loaded hydrogel based on a supramolecular polymeric prodrug

被引：71
|
作者：
Xiong, Lu [1 ]
Luo, Qiaojie [2 ]
Wang, Ying [1 ]
Li, Xiaodong [2 ]
Shen, Zhiquan [1 ]
Zhu, Weipu [1 ]
机构：
[1] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Affiliated Stomatol Hosp, Hangzhou 310006, Zhejiang, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 78期
基金：
中国国家自然科学基金;
关键词：
CLICK CHEMISTRY; ANTICANCER DRUGS; DELIVERY SYSTEMS; CANCER-THERAPY; RELEASE; MICELLES; PH; NANOPARTICLES; PACLITAXEL; MICROSPHERES;
D O I：
10.1039/c5cc06025g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We reported a novel injectable doxorubicin-loaded hydrogel based on host-guest interaction and Schiff's base reaction. A supramolecular polymeric prodrug was prepared through the inclusion of adamantane-modified doxorubicin into the beta-cyclodextrin cavity on the polyaldehyde dextran chain, which was in situ crosslinked by carboxymethyl chitosan.
引用
收藏
页码：14644 / 14647
页数：4
相关论文
共 50 条
  • [1] An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
    Pape, A. C. H.
    Bakker, Maarten H.
    Tseng, Cheyenne C. S.
    Bastings, Maartje M. C.
    Koudstaal, Stefan
    Agostoni, Pierfrancesco
    Chamuleau, Steven A. J.
    Dankers, Patricia Y. W.
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2015, (100):
  • [2] Injectable Coacervate Hydrogel for Delivery of Anticancer Drug-Loaded Nanoparticles in vivo
    Lee, Ashlynn L. Z.
    Voo, Zhi Xiang
    Chin, Willy
    Ono, Robert J.
    Yang, Chuan
    Gao, Shujun
    Hedrick, James L.
    Yang, Yi Yan
    ACS APPLIED MATERIALS & INTERFACES, 2018, 10 (16) : 13274 - 13282
  • [3] An injectable drug-loaded hydrogel using a "clickable" amphiphilic triblock copolymer as a precursor
    Gao, Lilong
    Zha, Guangyu
    Wang, Ying
    Luo, Qiaojie
    Zhu, Weipu
    Shen, Zhiquan
    Li, Xiaodong
    POLYMER CHEMISTRY, 2015, 6 (48) : 8240 - 8243
  • [4] Dynamic agent of an injectable and self-healing drug-loaded hydrogel for embolization therapy
    Zhou, Xiaqing
    Li, Yongsan
    Chen, Shuang
    Fu, Ya-nan
    Wang, Shihui
    Li, Guofeng
    Tao, Lei
    Wei, Yen
    Wang, Xing
    Liang, Jun F.
    COLLOIDS AND SURFACES B-BIOINTERFACES, 2018, 172 : 601 - 607
  • [5] Combining Ultra-High Drug-Loaded Micelles and Injectable Hydrogel Drug Depots for Prolonged Drug Release
    Luebtow, Michael M.
    Lorson, Thomas
    Finger, Tamara
    Groeber-Becker, Florian-Kai
    Luxenhofer, Robert
    MACROMOLECULAR CHEMISTRY AND PHYSICS, 2020, 221 (01)
  • [6] Drug-loaded polymeric nanoparticles: a review
    de Castro, Karine Cappuccio
    Costa, Josiel Martins
    Campos, Maria Gabriela Nogueira
    INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, 2022, 71 (01) : 1 - 13
  • [7] Thermosensitive injectable dual drug-loaded chitosan-based hybrid hydrogel for treatment of orthopedic implant infections
    Akhlaghi, Neda
    Najafpour-Darzi, Ghasem
    CARBOHYDRATE POLYMERS, 2023, 320
  • [8] Injectable Drug-Loaded Nanocarriers for Lung Cancer Treatments
    Yu, Huang-Ping
    Aljuffali, Ibrahim A.
    Fang, Jia-You
    CURRENT PHARMACEUTICAL DESIGN, 2017, 23 (03) : 481 - 494
  • [9] Injectable drug-loaded polysaccharide hybrid hydrogels for hemostasis
    Cao, Jinying
    Xiao, Ling
    Shi, Xiaowen
    RSC ADVANCES, 2019, 9 (63) : 36858 - 36866
  • [10] Injectable, ROS-scavenging, drug-loaded hydrogel dressings of natural origin for oral postoperative care
    Xu, Fan
    Zhang, Qiang
    Liu, Shuying
    Zhao, Yulong
    MATERIALS TODAY COMMUNICATIONS, 2023, 35
12345