Novel SNPs in IGF1, GHR and IGFBP-3 genes reveal significant association with growth traits in Indian goat breeds

被引：18

作者：

Sharma, Anurodh ^{[1
]}

Dutt, Gautam ^{[2
]}

Sivalingam, Jayakumar ^{[1
]}

Singh, M. K. ^{[3
]}

Pathodiya, O. P. ^{[4
]}

Khadda, B. S. ^{[5
]}

Dixit, S. P. ^{[1
]}

机构：

[1] NBAGR, Karnal, Haryana, India

[2] Dr BR Ambedkar Univ, Agra, Uttar Pradesh, India

[3] Cent Inst Res Goats, Mathura, India

[4] Maharana Pratap Univ Agr & Technol, Udaipur, Rajasthan, India

[5] Cent Hort Expt Stn, Godhara, Gujarat, India

来源：

SMALL RUMINANT RESEARCH | 2013年 / 115卷 / 1-3期

关键词：

IGF-1; GHR and IGFBP-3; SNP; Jamunapari; Sirohi; Goat; SINGLE NUCLEOTIDE POLYMORPHISMS; HORMONE RECEPTOR GENES; I GENE; INSULIN; INSULIN-LIKE-GROWTH-FACTOR-1; CATTLE; SIZE; BONE;

D O I：

10.1016/j.smallrumres.2013.08.001

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

The present study was conducted to investigate the effect of genetic polymorphisms in IGF1, GHR and IGFBP-3 genes on body weight of Sirohi and Jamunapari breeds of India. A panel of 80 samples belonging to nine Indian goat breeds was used for SNP identification and a total of 18 SNPs in IGF1, 5 SNPs in GHR and 8 SNPS in IGFBP-3 genes were identified. All the SNPs identified in nine breeds were genotyped in 309 goats. Statistical analysis revealed that two SNPs of IGF-1, one SNP of GHR and one SNP of IGFBP-3 genes have significant association with body weight in Sirohi breed of goat at different ages and only 1 SNP of GHR gene was found to be associated with body weight at birth in Jamunapari breed of goat. The findings of the present study can be used for selection of animals with superior growth performance. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：7 / 14

页数：8

共 28 条

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Sharma, Anurodh
Dutt, Gautam
Jayakumar, S.
Saroha, Vinita
Dixit, S. P.
JOURNAL OF APPLIED ANIMAL RESEARCH, 2014, 42 (03) : 361 - 365
[2] Genetic variability of bovine GHR, IGF-1 and IGFBP-3 genes in Indian cattle and buffalo
Ramesha, K. P.
Rao, Akhila
Basavaraju, M.
Geetha, G. R.
Kataktalware, M. A.
Jeyakumar, S.
SOUTH AFRICAN JOURNAL OF ANIMAL SCIENCE, 2015, 45 (05) : 485 - 493
[3] Association between hepatic steatosis and serum IGF1 and IGFBP-3 levels in a population-based sample
Voelzke, Henry
Nauck, Matthias
Rettig, Rainer
Doerr, Marcus
Higham, Claire
Brabant, Georg
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EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2009, 161 (05) : 705 - 713
[4] Association analysis for SNPs of MSTN and IGFBP-3 genes with body size and other production traits in Liaoning Cashmere Goats
Sun, Yinggang
Cai, Weidong
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Xu, Yanan
Han, Di
Dou, Xingtang
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Lin, Guangyu
Wang, Lingling
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Fu, Shuqing
Wu, Yanzhi
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Zhang, Yu
Gu, Ming
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[5] EVALUATION OF POLYMORPHISM IN IGF-I AND IGFBP-3 GENES AND THEIR RELATIONSHIP WITH TWINNING RATE AND GROWTH TRAITS IN MARKHOZ GOATS
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ANNALS OF ANIMAL SCIENCE, 2017, 17 (01): : 89 - 103
[6] Identification of SNPs in the second intron of IGF2BP1 and their Association with growth traits in Nanjiang Yellow goat
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Xu, Liang
Leng, Junchen
Chen, Zitong
Chen, Yu.
Li, Li.
Zhang, Hongping
Li, Mingzhou
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ANIMAL BIOTECHNOLOGY, 2025, 36 (01)
[7] Novel SNPs in the caprine stearoyl-CoA desaturase (SCD) and decorin (DCN) genes that are associated with growth traits in Chinese goat breeds
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Xianyong Lan
Chunlei Zhang
Yujiao Qu
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Xingtang Fang
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Molecular Biology Reports, 2011, 38 : 3121 - 3127
[8] Novel SNPs in the caprine stearoyl-CoA desaturase (SCD) and decorin (DCN) genes that are associated with growth traits in Chinese goat breeds
Chen, Zhongqi
Sun, Jiajie
Li, Zhuanjian
Lan, Xianyong
Zhang, Chunlei
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MOLECULAR BIOLOGY REPORTS, 2011, 38 (05) : 3121 - 3127
[9] Genotyping of Novel SNPs in BMPR1B, BMP15, and GDF9 Genes for Association with Prolificacy in Seven Indian Goat Breeds
Ahlawat, Sonika
Sharma, Rekha
Roy, Manoranjan
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ANIMAL BIOTECHNOLOGY, 2016, 27 (03) : 199 - 207
[10] Energy homeostasis genes modify the association between serum concentrations of IGF-1 and IGFBP-3 and breast cancer risk
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Martinez-Matsushita, Louis
Angeles-Llerenas, Angelica
Gomez-Flores-Ramos, Liliana
Wolff, Roger K.
Baumgartner, Kathy B.
Hines, Lisa M.
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Flores-Luna, Lourdes
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SCIENTIFIC REPORTS, 2022, 12 (01)

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