Caffeoyl glucosides from Nandina domestica inhibit LPS-induced endothelial inflammatory responses

被引：14

作者：

Kulkarni, Roshan R. ^{[1
]}

Lee, Wonhwa ^{[2
,3
]}

Jang, Tae Su ^{[4
]}

Lee, JungIn ^{[1
]}

Kwak, Soyoung ^{[2
]}

Park, Mi Seon ^{[5
]}

Lee, Hyun-Shik ^{[6
]}

Bae, Jong-Sup ^{[2
]}

Na, MinKyun ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Kyungpook Natl Univ, Pharmaceut Sci Res Inst, CMRI, Coll Pharm, Taegu 702701, South Korea

[3] Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Plus KNU Biomed Convergence Program BK21, Taegu 702701, South Korea

[4] Seoul Natl Univ, Inst Green Bio Sci & Technol, Seoul 151742, South Korea

[5] Natl Fisheries Res & Dev Inst, Aquaculture Management Div, Busan 619705, South Korea

[6] Kyungpook Natl Univ, Sch Life Sci, CMRI, ABRC,Plus KNU Creat BioRes Grp BK21, Taegu 702701, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 22期

基金：

新加坡国家研究基金会;

关键词：

Nandina domestica Thunb; Berberidaceae; Caffeoyl glucosides; Vascular inflammatory disorders; NF-KAPPA-B; PERMEABILITY; DYSFUNCTION; SEPSIS; LEAVES; CELLS; CONSTITUENTS; ACTIVATION; GLYCOSIDES; ESTER;

D O I：

10.1016/j.bmcl.2015.09.031

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Endothelial dysfunction is a key pathological feature of many inflammatory diseases, including sepsis. In the present study, a new caffeoyl glucoside (1) and two known caffeoylated compounds (2 and 3) were isolated from the fruits of Nandina domestica Thunb. (Berberidaceae). The compounds were investigated for their effects against lipopolysaccharide (LPS)-mediated endothelial inflammatory responses. At 20 mu M, 1 and 2 inhibited LPS-induced hyperpermeability, adhesion, and migration of leukocytes across a human endothelial cell monolayer in a dose-dependent manner suggesting that 1 and 2 may serve as potential scaffolds for the development of therapeutic agents to treat vascular inflammatory disorders. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：5367 / 5371

页数：5

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