Synthesis of some new thiazolo[3,2-a]pyrido[2,3-d]pyrimidinones and isoxazolo[5′,4′:4,5]thiazolo[3,2-a]pyrido[2,3-d]pyrimidinone

被引：14
|
作者：
El-Gazzar, ABA [1 ]
Gaafar, AM [1 ]
Aly, AS [1 ]
机构：
[1] Natl Res Ctr, Cairo, Egypt
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2002年 / 177卷 / 01期
关键词：
6-aminothiouracil; alpha; beta-unsaturated ketones; spectroscopic analysis (NMR; mass);
D O I：
10.1080/10426500210230
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
6-Amino-2,3-dihydro-2-thioxo-4(1H)-pyrimidinone I reacts in boiling DMF with a cyclic alpha, beta-unsaturated ketones 2 affording the pyrido [2,3-d]pyrimidinone 6a,b, the latter compound condensed with aldehyde in presence of chloroacetic acid to yield thiazolo[3,2-a] pyrido [2,3-d]-pyrimidinones (7, 8) respectively. The alkylation of pyrido-pyrimidinone it gave the 2-alkylthio derivatives 10a-e, compound 10b cyclized to thiazolopyridopyrimidinone derivative 13. Also, the condensation of compounds 7a,b with hydoxylamine gave the corresponding isoxazolo[5',4':4,5]thiazolo[3,2-a]pyrido[2,3-d]pyrimidinone.
引用
收藏
页码：45 / 58
页数：14
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