Biomarkers of Inflammatory Bowel Disease: From Classical Laboratory Tools to Personalized Medicine

被引：31
|
作者：
Viennois, Emilie [1 ,2 ]
Zhao, Yuan [1 ,3 ]
Merlin, Didier [1 ,2 ]
机构：
[1] Georgia State Univ, Inst Biomed Sci, Ctr Diagnost & Therapeut, Atlanta, GA 30302 USA
[2] Atlanta Vet Affairs Med Ctr, Decatur, GA USA
[3] Fudan Univ, Zhongshan Hosp, Dept Gastroenterol, Shanghai 200433, Peoples R China
来源：
INFLAMMATORY BOWEL DISEASES | 2015年 / 21卷 / 10期
基金：
美国国家卫生研究院;
关键词：
IBD; biomarkers; signature; C-REACTIVE PROTEIN; GELATINASE-ASSOCIATED LIPOCALIN; ACTIVE ULCERATIVE-COLITIS; FECAL CALPROTECTIN; CROHNS-DISEASE; CIRCULATING MICRORNA; EXPRESSION PROFILES; NONINVASIVE MARKER; SURROGATE MARKERS; ACTIVITY INDEX;
D O I：
10.1097/MIB.0000000000000444
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Diagnostics of inflammatory bowel diseases (IBDs) currently relies on a combination of biological and morphological tests. The current method of diagnostic remains a critical challenge for physicians in part due to their invasiveness and also for their limitations in term of diagnosis, prognosis, disease activity and severity assessment, and therapeutic outcomes. Laboratory biomarkers can be used in the diagnosis and management of IBD, but none of them has been proven to be ideal. Increasing efforts are being made to discover new biomarkers that can discriminate between the types of IBD, predict future responses to treatment, and aid in differential diagnosis, treatment planning, and prognosis prediction. This review addresses the potential for current biomarkers and the emergence of the concept of biomarker signatures in IBD diagnostic and personalized medicine.
引用
收藏
页码：2467 / 2474
页数：8
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