A Case-control Study on Risk Factors for Severe Hand, Foot and Mouth Disease

被引：12

作者：

Zhang, Dingmei ^{[1
]}

Li, Ruolin ^{[1
]}

Zhang, Wangjian ^{[1
]}

Li, Guowei ^{[2
]}

Ma, Zhanzhong ^{[3
]}

Chen, Xiashi ^{[1
]}

Du, Zhicheng ^{[1
]}

Li, Zhiyuan ^{[1
]}

Guo, Pi ^{[1
]}

Lin, Zhuochen ^{[1
]}

Lu, Jiahai ^{[1
]}

Hao, Yuantao ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Publ Hlth, Guangzhou, Guangdong, Peoples R China

[2] Zhengzhou Ctr Dis Control & Prevent, Zhengzhou, Peoples R China

[3] Yuebei Peoples Hosp, Dept Clin Lab, Shaoguan, Peoples R China

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

ENTEROVIRUS; 71; INFECTION; EPIDEMIC; OUTBREAK; CHINA;

D O I：

10.1038/srep40282

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The objective of this study was to identify potential risk factors for severe hand, foot and mouth disease (HFMD). In this case-control study, 459 severe HFMD patients and 246 mild HFMD patients from Guangdong province and Henan province, China were included. Data comprising demographic characteristics, clinical symptoms and signs, laboratory findings and other factors were collected. Univariate analysis revealed 30 factors associated with severe cases. Further multivariate analysis indicated four independent risk factors: fatigue (p < 0.01, odd ratio [OR] = 204.7), the use of glucocorticoids (p = 0.03, OR = 10.44), the use of dehydrant drugs (p < 0.01, OR = 73.7) and maculopapular rash (p < 0.01, OR = 84.4); and one independent protective factor: herpes or ulcers in mouth (p = 0.01, OR = 0.02). However, more systematic research and validation are needed to understand the underlying risk factors for severe HFMD.

引用

页数：7

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