Catalyst- and solvent-free approach to 2-arylated quinolines via [5+1] annulation of 2-methylquinolines with diynones

被引：6
|
作者：
Zhao, Hai-Yuan [1 ,2 ]
Wu, Fu-Song [2 ]
Yang, Li [3 ]
Liang, Ying [1 ]
Cao, Xiao-Lin [2 ]
Wang, Heng-Shan [2 ]
Pan, Ying-Ming [2 ]
机构：
[1] Guilin Univ Elect Technol, Sch Life & Environm Sci, Guilin 541004, Peoples R China
[2] Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China
[3] Guangxi Zhuang Autonomous Reg Forestry Res Inst, Guangxi Key Lab Special Nonwood Forest Cultivat &, Nanning 530002, Peoples R China
来源：
RSC ADVANCES | 2018年 / 8卷 / 09期
基金：
中国国家自然科学基金;
关键词：
CROSS-COUPLING REACTIONS; GAMMA-AMINO-ALCOHOLS; CYCLOOXYGENASE-2; INHIBITORS; BIOLOGICAL EVALUATION; ASYMMETRIC CATALYSIS; SECONDARY ALCOHOLS; PINCER COMPLEXES; DIRECT ARYLATION; BOND ACTIVATION; ARYL HALIDES;
D O I：
10.1039/c7ra12716b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel route for the synthesis of 2-arylated quinolines through a [5 + 1] annulation directly from 2-methylquinolines and diynones under catalyst-free and solvent-free conditions was disclosed. This synthetic process was atom-economic, with good tolerance of a broad range of functional groups, and with great practical worth.
引用
收藏
页码：4584 / 4587
页数：4
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