It has to be the αv: myofibroblast integrins latent TGF-β1

被引：53
|
作者：
Hinz, Boris [1 ]
机构：
[1] Univ Toronto, Fac Dent, Matrix Dynam Grp, Lab Tissue Repair & Regenerat, Toronto, ON, Canada
来源：
NATURE MEDICINE | 2013年 / 19卷 / 12期
关键词：
BETA; FIBROSIS;
D O I：
10.1038/nm.3421
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cell-mediated activation of latent TGF-β1 is a key promoting event in fibrosis in all organs. A new study shows that specific targeting of the αv subunit of integrins in fibrogenic myofibroblasts effectively reduces developing and established fibrosis in liver, kidneys and lungs (pages 1617–1624). © 2013 Nature America, Inc. All rights reserved.
引用
收藏
页码：1567 / 1568
页数：2
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