Antibacterial activity of halogenated sesquiterpenes from Malaysian Laurencia spp.

被引：51
|
作者：
Vairappan, Charles Santhanaraju [1 ]
Suzuki, Minoru [2 ]
Ishii, Takahiro [2 ]
Okino, Tatsufumi [2 ]
Abe, Tsuyoshi [3 ]
Masuda, Michio [4 ]
机构：
[1] Univ Malaysia Sabah, Inst Trop Biol & Conservat, Lab Nat Prod Chem, Kota Kinabalu 88999, Sabah, Malaysia
[2] Hokkaido Univ, Grad Sch Environm Earth Sci, Div Mat Sci, Sapporo, Hokkaido 0600810, Japan
[3] Hokkaido Univ Museum, Sapporo, Hokkaido 0600810, Japan
[4] Hokkaido Univ, Grad Sch Sci, Div Biol Sci, Sapporo, Hokkaido 0600810, Japan
来源：
PHYTOCHEMISTRY | 2008年 / 69卷 / 13期
关键词：
Laurencia sp; Rhodomelaceae; Bioactive metabolites; Halogenated sesquiterpenes; Halogenated C-15 acetogenins; Antibacterial activity;
D O I：
10.1016/j.phytochem.2008.06.015
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
During our studies on Malaysian Laurencia species, brominated metabolites, tiomanene, acetylmajapolene B, and acetylmajapolene A were isolated from an unrecorded species collected at Pulau Tioman, Pahang along with known majapolene B and majapolene A. Acetylmajapolene A was a mixture of diastereomers as in the case of majapolene A. Tiomanene may be a plausible precursor for acetylmajapolenes B and A. In addition, three known halogenated sesquiterpenes and two known halogenated C-15 acetogenins were found from other two unrecorded species collected at Pulau Karah, Terengganu and Pulau Nyireh, Terengganu, respectively. Some of these halogenated metabolites showed moderate antibacterial activity against some marine bacteria. (c) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2490 / 2494
页数：5
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