Immunogenicity for 16 serotypes of a unique schedule of pneumococcal vaccines in a high-risk population

被引：15
|
作者：
Leach, Amanda J. [1 ]
Morris, Peter S. [1 ,2 ]
Mackenzie, Grant [1 ]
McDonnell, Joseph [1 ]
Balloch, Anne [3 ]
Carapetis, Jonathan [1 ,2 ]
Tang, Mimi [3 ]
机构：
[1] Charles Darwin Univ, Menzies Sch Hlth Res, Darwin, NT 0909, Australia
[2] Flinders Univ S Australia, NT Clin Sch, Darwin, NT, Australia
[3] Murdoch Childrens Res Inst, Melbourne, Vic, Australia
来源：
VACCINE | 2008年 / 26卷 / 31期
关键词：
immunogenicity; 16; serotypes; pneumococcal vaccines; high-risk population;
D O I：
10.1016/j.vaccine.2008.05.012
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Background: A unique schedule of 7-valent pneumococcal conjugate vaccine (7PCV) at 2,4 and 6 months of age and 23-valent pneumococcal polysaccharide vaccine (23PPV) at 18 months commenced for Australian Aboriginal infants in 2001. Methods: Anti-capsular IgG concentrations in vaccinated and non-vaccinated (historic control) infants were determined (blinded) by (22F absorbed) ELISA. Results: One month after dose 3 of 7PCV, geometric mean concentrations (GMCs) were > 1.95 mu g/ml and at least 89% of infants had IgG > 035 mu g/ml to all 7PCV serotypes. One month post-23PPV, IgG to 7PCV serotypes was > 035 mu g/ml for more than 96% infants (> 1.3 mu g/ml for at least 70%), and IgG to non-7PCV serotypes was > 035 mu g/ml for more than 50% infants (including serotype 6A, but not 12F (17%) or 19A (44%). Conclusion: 7PCV and 23PPV are immunogenic in this population. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3885 / 3891
页数：7
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