Effect of Induced Pluripotent Stem Cell Technology in Blood Banking

被引:7
|
作者
Focosi, Daniele [1 ]
Pistello, Mauro [2 ,3 ,4 ]
机构
[1] Univ Pisa, Azienda Osped, North Western Tuscany Blood Bank, I-56127 Pisa, Italy
[2] Univ Pisa, Retrovirus Ctr, I-56127 Pisa, Italy
[3] Univ Pisa, Dept Translat Res, Virol Sect, I-56127 Pisa, Italy
[4] Univ Pisa, Azienda Osped, Virol Unit, I-56127 Pisa, Italy
关键词
IN-VITRO; EX-VIVO; PLATELET TRANSFUSIONS; GROUP-A; C-MYC; GENERATION; DIFFERENTIATION; ERYTHROCYTES; FIBROBLASTS; INDUCTION;
D O I
10.5966/sctm.2015-0257
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Population aging has imposed cost-effective alternatives to blood donations. Artificial blood is still at the preliminary stages of development, and the need for viable cells seems unsurmountable. Because large numbers of viable cells must be promptly available for clinical use, stem cell technologies, expansion, and banking represent ideal tools to ensure a regular supply. Provided key donors can be identified, induced pluripotent stem cell (iPSC) technology could pave the way to a new era in transfusion medicine, just as it is already doing in many other fields of medicine. The present review summarizes the current state of research on iPSC technology in the field of blood banking, highlighting hurdles, and promises.
引用
收藏
页码:269 / 274
页数:6
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