Safety, Efficacy and Biomarker Outcomes of a Novel, Intra-Articular, Injectable, Wnt Inhibitor (SM04690) in the Treatment of Osteoarthritis of the Knee: Interim, Exploratory Analysis of Results from a Randomized, Double-Blind, Placebo-Controlled Phase 1 Study

被引：0

作者：

Yazici, Yusuf ^{[1
]}

McAlindon, Timothy E. ^{[2
]}

Fleischmann, Roy ^{[3
]}

Gibofsky, Allan ^{[4
,5
]}

Lane, Nancy E. ^{[6
]}

Kivitz, Alan J. ^{[7
]}

Skrepnik, Nebojsa ^{[8
]}

Armas, Eddie ^{[9
]}

Swearingen, Christopher J. ^{[1
]}

DiFrancesco, Anita ^{[1
]}

Tambiah, Jeyanesh R. S. ^{[1
]}

Hood, John ^{[1
]}

Hochberg, Marc C. ^{[10
]}

机构：

[1] Samumed, San Diego, CA USA

[2] Tufts Med Ctr, Boston, MA USA

[3] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA

[4] Weill Cornell Med Coll, New York, NY USA

[5] Hosp Special Surg, New York, NY 10021 USA

[6] UC Davis Med Ctr, Sacramento, CA USA

[7] Altoona Ctr Clin Res, Duncansville, PA USA

[8] Tucson Orthopaed Inst, Tucson, AZ USA

[9] Well Pharma Med Res, Miami, FL USA

[10] Univ Maryland, Sch Med, Baltimore, MD 21201 USA

来源：

ARTHRITIS & RHEUMATOLOGY | 2015年 / 67卷

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

312

引用

页数：3

共 50 条

[1] Radiographic Outcomes from a Randomized, Double-Blind, Placebo-Controlled, Phase 1 Study of a Novel, Intra-Articular, Injectable, Wnt Inhibitor (SM04690) in the Treatment of Osteoarthritis of the Knee
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Simsek, Ismail
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Tambiah, Jeymi
Yazici, Yusuf
ARTHRITIS & RHEUMATOLOGY, 2016, 68
[2] SAFETY, CLINICAL AND IMAGING OUTCOMES OF A NOVEL, INTRA-ARTICULAR, INJECTABLE, WNT INHIBITOR (SM04690) IN THE TREATMENT OF OSTEOARTHRITIS OF THE KNEE: EXPLORATORY ANALYSIS OF RESULTS FROM A 24 WEEK, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PHASE 1 STUDY
Yazici, Y.
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Fleischmann, R. M.
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Lane, N. E.
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Majumdar, S.
Strand, V.
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DiFrancesco, A.
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[3] RADIOGRAPHIC OUTCOMES FROM A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE 2 STUDY OF A NOVEL, INTRA-ARTICULAR, INJECTABLE, WNT PATHWAY INHIBITOR (SM04690) IN THE TREATMENT OF OSTEOARTHRITIS OF THE KNEE: WEEK 26 INTERIM ANALYSIS
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[4] CLINICAL OUTCOMES FROM A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE 2 STUDY OF A NOVEL, INTRA-ARTICULAR, INJECTABLE, WNT PATHWAY INHIBITOR (SM04690) FOR THE TREATMENT OF KNEE OSTEOARTHRITIS: WEEK 26 INTERIM ANALYSIS
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[5] OMERACT-OARSI 'STRICT RESPONDERS' ANALYSIS FROM RESULTS OF A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PHASE 1 STUDY OF A NOVEL, INTRA-ARTICULAR, INJECTABLE, WNT INHIBITOR (SM04690) IN THE TREATMENT OF OSTEOARTHRITIS OF THE KNEE
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[6] Results from a 52 Week Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of a Novel, Intra-Articular, Wnt Pathway Inhibitor (SM04690) for the Treatment of Knee Osteoarthritis
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[7] Magnetic Resonance Imaging Outcomes Using an Intra-Articular Injection (SM04690) in the Treatment of Osteoarthritis of the Knee: Interim, Exploratory Analysis of Results from a Randomized, Double-Blind, Placebo-Controlled, Phase 1 Study
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Swearingen, Christopher J.
DiFrancesco, Anita
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Hood, John
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ARTHRITIS & RHEUMATOLOGY, 2015, 67
[8] RESULTS FROM A 52-WEEK RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE 2 STUDY OF A NOVEL, INTRA-ARTICULAR WNT PATHWAY INHIBITOR (SM04690) FOR THE TREATMENT OF KNEE OSTEOARTHRITIS
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[10] Analysis of Pain and Function Components in Omeract-Oarsi Strict Responders from a Randomized, Double-Blind, Placebo-Controlled, Phase 1 Study of a Novel, Intra-Articular, Injectable, Wnt Inhibitor (SM04690) in the Treatment of Osteoarthritis of the Knee
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