A Novel Histone Deacetylase 6 Inhibitor, CKD-H059 Inhibits the Inflammatory Response in Rheumatoid Arthritis

被引：0
|
作者：
Jang, Yu Jin [1 ,2 ]
Oh, Bo Ram [2 ,3 ]
Lim, Hyojin [4 ]
Bae, Daekwon [4 ]
Ha, Nina [4 ]
Choi, Young Il [5 ]
Park, Jin Kyun [6 ]
Lee, Eun Young [6 ]
Lee, Eun Bong [6 ]
Song, Yeong Wook [2 ,3 ,6 ]
机构：
[1] Seoul Natl Univ, Dept Mol Med & Biopharmaceut Sci, BK Plus Grad Sch Convergence Sci & Technol 21, Seoul, South Korea
[2] Seoul Natl Univ, Coll Med, Seoul, South Korea
[3] Seoul Natl Univ, Dept Mol Med & Biopharmaceut Sci, Grad Sch Convergence Sci & Technol, Seoul, South Korea
[4] CKD Pharmaceut Co, Dept Pharmacol & Toxicol, CKD Res Inst, Seoul, South Korea
[5] CKD Pharmaceut Co, Pharmacol Lab, Hyo Jong Res Labs, Yongin, South Korea
[6] Seoul Natl Univ, Dept Internal Med, Div Rheumatol, Seoul, South Korea
来源：
ARTHRITIS & RHEUMATOLOGY | 2015年 / 67卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
1628
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Therapeutic Role of a Novel Histone Deacetylase 6 Inhibitor, CKD-M808, in Rheumatoid Arthritis
    Shon, Sehui
    Park, Ji Soo
    Bae, Daekwon
    Ha, Nina
    Choi, Young Il
    Park, Jin Kyun
    Lee, Eun Young
    Lee, Eun Bong
    Song, Yeong Wook
    ARTHRITIS & RHEUMATOLOGY, 2016, 68
  • [2] CKD-506, a Novel Inhibitor of Histone Deacetylase 6 (HDAC6) Has a Therapeutic Potential in Rheumatoid Arthritis and Inflammatory Bowel Disease
    Shin, Jieun
    Ha, Nina
    Bae, Daekwon
    Suh, Dong-Hyeon
    Jang, Yu Jin
    Shon, Sehui
    Baek, Ji-Yeon
    Jun, Jae Hyun
    Lee, Yong Jae
    Lee, Changsik
    Kim, Sei-Hwan
    Yu, Hosung
    Choi, Young Il
    Ryu, Keun Ho
    Lee, Soung-Min
    Song, Yeong Wook
    Seo, Su K.
    Kim, Seong Kon
    ARTHRITIS & RHEUMATOLOGY, 2017, 69
  • [3] Therapeutic potential of CKD-506, a novel selective histone deacetylase 6 inhibitor, in a murine model of rheumatoid arthritis
    Jin Kyun Park
    Yu Jin Jang
    Bo Ram Oh
    Jieun Shin
    Daekwon Bae
    Nina Ha
    Young il Choi
    Gi Soo Youn
    Jinseu Park
    Eun Young Lee
    Eun Bong Lee
    Yeong Wook Song
    Arthritis Research & Therapy, 22
  • [4] Therapeutic potential of CKD-506, a novel selective histone deacetylase 6 inhibitor, in a murine model of rheumatoid arthritis
    Park, Jin Kyun
    Jang, Yu Jin
    Oh, Bo Ram
    Shin, Jieun
    Bae, Daekwon
    Ha, Nina
    Choi, Young Il
    Youn, Gi Soo
    Park, Jinseu
    Lee, Eun Young
    Lee, Eun Bong
    Song, Yeong Wook
    ARTHRITIS RESEARCH & THERAPY, 2020, 22 (01)
  • [5] Therapeutic effect of a novel histone deacetylase 6 inhibitor, CKD-L, on collageninduced arthritis in vivo and regulatory T cells in rheumatoid arthritis in vitro
    Oh, Bo Ram
    Suh, Dong-Hyeon
    Bae, Daekwon
    Ha, Nina
    Choi, Young Il
    Yoo, Hyun Jung
    Park, Jin Kyun
    Lee, Eun Young
    Lee, Eun Bong
    Song, Yeong Wook
    ARTHRITIS RESEARCH & THERAPY, 2017, 19
  • [6] Therapeutic effect of a novel histone deacetylase 6 inhibitor, CKD-L, on collagen-induced arthritis in vivo and regulatory T cells in rheumatoid arthritis in vitro
    Bo Ram Oh
    Dong-hyeon Suh
    Daekwon Bae
    Nina Ha
    Young Il Choi
    Hyun Jung Yoo
    Jin Kyun Park
    Eun Young Lee
    Eun Bong Lee
    Yeong Wook Song
    Arthritis Research & Therapy, 19
  • [7] Therapeutic Effect of a Novel Histone Deacetylase 6 Inhibitor, CKD-L, on Collagen Induced Arthritis and Peripheral Blood Mononuclear Cells from Patients with Rheumatoid Arthritis.
    Oh, Bo Ram
    Lim, Hyojin
    Bae, Daekwon
    Ha, Nina
    Choi, Young Il
    Yoo, Hyun Jung
    Park, Jin Kyun
    Lee, Eun Young
    Lee, Eun Bong
    Song, Yeong Wook
    ARTHRITIS & RHEUMATOLOGY, 2014, 66 : S1023 - S1023
  • [8] THERAPEUTIC EFFECT OF A NEW HISTONE DEACETYLASE 6 INHIBITOR, CKD-L, ON COLLAGEN INDUCED ARTHRITIS AND PERIPHERAL BLOOD MONONUCLEAR CELLS FROM PATIENTS WITH RHEUMATOID ARTHRITIS IN VITRO
    Oh, B.
    Lim, H.
    Ko, E. H.
    Ha, N.
    Yoo, H. J.
    Park, J. K.
    Lee, E. Y.
    Lee, E. B.
    Song, Y. W.
    ANNALS OF THE RHEUMATIC DISEASES, 2014, 73 : 509 - 510
  • [9] Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients
    Gillespie, Justin
    Savic, Sinisa
    Wong, Chi
    Hempshall, Aiden
    Inman, Martyn
    Emery, Paul
    Grigg, Ronald
    McDermott, Michael F.
    ARTHRITIS AND RHEUMATISM, 2012, 64 (02): : 418 - 422
  • [10] HISTONE DEACETYLASE 1: A NOVEL THERAPEUTIC TARGET FOR PATIENTS WITH RHEUMATOID ARTHRITIS
    Goeschl, L.
    Mueller, L.
    Saferding, V.
    Baecklund, J.
    Knapp, S.
    Mathias, P.
    Scheinecker, C.
    Ellmeier, W.
    Steiner, G.
    Bonelli, M.
    ANNALS OF THE RHEUMATIC DISEASES, 2018, 77 : A63 - A63
12345