A search for the physical basis of the genetic code

被引：3

作者：

Moghadam, S. Arbabi ^{[1
]}

Klobukowski, M. ^{[2
]}

Tuszynski, J. A. ^{[1
,3
,4
]}

机构：

[1] Univ Alberta, Dept Phys, Edmonton, AB T6G 2E1, Canada

[2] Univ Alberta, Dept Chem, Edmonton, AB T6G 2N4, Canada

[3] Univ Alberta, Dept Oncol, Edmonton, AB T6G 1Z2, Canada

[4] Politecn Torino, DIMEAS, Turin, Italy

来源：

BIOSYSTEMS | 2020年 / 195卷

关键词：

DNA; Genetic code; Amino acid; Probability distribution; Gibbs free energy; Redundancy; Codon; MOLECULAR-ORBITAL METHODS; SEMIEMPIRICAL METHODS; HARTREE-FOCK; ERROR MINIMIZATION; ESCHERICHIA-COLI; ATP-HYDROLYSIS; FREE-ENERGY; BASIS-SET; EVOLUTION; ORIGIN;

D O I：

10.1016/j.biosystems.2020.104148

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

DNA contains the genetic code, which provides complete information about the synthesis of proteins in every living cell. Each gene encodes for a corresponding protein but most of the DNA sequence is non-coding. In addition to this non-coding part of the DNA, there is another redundancy, namely a multiplicity of DNA triplets (codons) corresponding to code for a given amino acid. In this paper we investigate possible physical reasons for the coding redundancy, by exploring free energy considerations and abundance probabilities as potential insights.

引用

页数：37

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