Synthesis of polysubstituted β-amino cyclohexane carboxylic acids via Diels-Alder reaction using Ni(II)-complex stabilized β-alanine derived dienes

被引：8

作者：

Ding, Xiao ^{[1
]}

Wang, Hengshuai ^{[1
]}

Wang, Jiang ^{[1
]}

Wang, Sinan ^{[1
]}

Lin, Daizong ^{[1
]}

Lv, Li ^{[1
]}

Zhou, Yu ^{[1
]}

Luo, Xiaomin ^{[1
]}

Jiang, Hualiang ^{[1
]}

Luis Acena, Jose ^{[2
]}

Soloshonok, Vadim A. ^{[2
,3
]}

Liu, Hong ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

[2] Basque Fdn Sci, IKERBASQUE, Bilbao 48011, Spain

[3] Univ Basque Country UPV EHU, San Sebastian, Spain

来源：

AMINO ACIDS | 2013年 / 44卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Diels-Alder reaction; Nickel (II); beta-Alanine; beta-Aminocyclohexane carboxylic acids; MICHAEL ADDITION-REACTIONS; EFFICIENT ASYMMETRIC-SYNTHESIS; NUCLEOPHILIC GLYCINE EQUIVALENTS; SUBSTITUTED PYROGLUTAMIC ACIDS; VIRTUALLY COMPLETE CONTROL; CHIRAL NI(II) COMPLEX; LARGE-SCALE SYNTHESIS; ALPHA-AMINO; ALDOL REACTIONS; FACE DIASTEREOSELECTIVITY;

D O I：

10.1007/s00726-012-1404-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper describes the design and synthesis of a new class of beta-alanine derived dienes stabilized by Ni(II)-complex. Preliminary study of their Diels-Alder cycloaddition reactions with several types of dienophiles demonstrates their significant synthetic potential for the preparation of various polyfunctional beta-aminocyclohexane carboxylic acids.

引用

页码：791 / 796

页数：6

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