Structure homology and interaction redundancy for discovering virus-host protein interactions

被引：29
|
作者：
de Chassey, Benoit [1 ]
Meyniel-Schicklin, Laurene [2 ,3 ]
Aublin-Gex, Anne [2 ,3 ]
Navratil, Vincent [2 ,3 ]
Chantier, Thibaut [2 ,3 ]
Andre, Patrice [1 ,2 ,3 ]
Lotteau, Vincent [2 ,3 ]
机构：
[1] Hop Croix Rousse, Hosp Civils Lyon, Virol Lab, F-69004 Lyon, France
[2] INSERM, U1111, F-69007 Lyon, France
[3] Univ Lyon, Lyon, France
来源：
EMBO REPORTS | 2013年 / 14卷 / 10期
关键词：
interactome; prediction; protein interaction; structure; virus; NS1; PROTEIN; ACTIVATION; APOPTOSIS;
D O I：
10.1038/embor.2013.130
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Virus-host interactomes are instrumental to understand global perturbations of cellular functions induced by infection and discover new therapies. The construction of such interactomes is, however, technically challenging and time consuming. Here we describe an original method for the prediction of high-confidence interactions between viral and human proteins through a combination of structure and high-quality interactome data. Validation was performed for the NS1 protein of the influenza virus, which led to the identification of new host factors that control viral replication.
引用
收藏
页码：938 / 944
页数：7
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