HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma

被引:3
作者
Reszec, Joanna [1 ]
Zalewska, Renata [2 ]
Bernaczyk, Piotr [1 ]
Chyczewski, Lech [1 ]
机构
[1] Med Univ Bialystok, Dept Med Pathomorphol, PL-15269 Bialystok, Poland
[2] Med Univ Bialystok, Dept Ophthalmol, PL-15269 Bialystok, Poland
关键词
optic nerve axons; retinal ganglion cells; HIF-1; immunohistochemistry;
D O I
10.5603/FHC.2012.0063
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glaucoma is a result of increased intraocular pressure leading to damage to retinal ganglion cells and optic nerve axons. The aim of this study was to evaluate HIF-1 expression in optic nerve axons and retinal ganglion cells in 42 eyes enucleated because of complete glaucoma compared to eyes removed because of injury. The immunohistochemical reaction was done and specimens were examined under a light microscope. 57% of cases presented HIF-1 expression in the optic nerve axons, and 52.3% in the retinal ganglion cells. 20 out of 42 (47.6%) cases were HIF-1 positive both in the optic nerve axons and in the retinal ganglion cells, and the staining was evident mostly in the nuclear and perinuclear area. Our present results indicate that HIF-1 expression in hypoxic conditions in glaucoma might be a very crucial stage in damage to retinal ganglion cells and optic nerve axons, and might be a successful target for the implementation of neuroprotective drugs. (Folia Histochemica et Cytobiologica 2012, Vol. 50, No. 3, 456-459)
引用
收藏
页码:456 / 459
页数:4
相关论文
共 10 条
  • [1] Oxygen-dependent diseases in the retina: Role of hypoxia-inducible factors
    Arjamaa, Olli
    Nikinmaa, Mikko
    [J]. EXPERIMENTAL EYE RESEARCH, 2006, 83 (03) : 473 - 483
  • [2] Hypoxia Inducible Factor-1α (HIF-1α) and Some HIF-1 Target Genes are Elevated in Experimental Glaucoma
    Ergorul, Ceren
    Ray, Arjun
    Huang, Wei
    Wang, Dan Yi
    Ben, Yixin
    Cantuti-Castelvetri, Ippolita
    Grosskreutz, Cynthia L.
    [J]. JOURNAL OF MOLECULAR NEUROSCIENCE, 2010, 42 (02) : 183 - 191
  • [3] Gui DM, 2011, INT J OPHTHALMOL-CHI, V4, P40, DOI 10.3980/j.issn.2222-3959.2011.01.09
  • [4] HIF-1alpha and HIF-2alpha Are Differentially Activated in Distinct Cell Populations in Retinal Ischaemia
    Mowat, Freya M.
    Luhmann, Ulrich F. O.
    Smith, Alexander J.
    Lange, Clemens
    Duran, Yanai
    Harten, Sarah
    Shukla, Deepa
    Maxwell, Patrick H.
    Ali, Robin R.
    Bainbridge, James W. B.
    [J]. PLOS ONE, 2010, 5 (06):
  • [5] Endothelin, astrocytes and glaucoma
    Prasanna, Ganesh
    Krishnamoorthy, Raghu
    Yorio, Thomas
    [J]. EXPERIMENTAL EYE RESEARCH, 2011, 93 (02) : 170 - 177
  • [6] Comparison of the distribution of glial fibrillary acidic protein, heat shock protein 60, and hypoxia-inducible factor-1α in retinas from glaucomatous and normal canine eyes
    Savagian, Caitlin A.
    Dubielzig, Richard R.
    Nork, Michael
    [J]. AMERICAN JOURNAL OF VETERINARY RESEARCH, 2008, 69 (02) : 265 - 272
  • [7] Hypoxia-inducible factor 1α in the glaucomatous retina and optic nerve head
    Tezel, G
    Wax, MB
    [J]. ARCHIVES OF OPHTHALMOLOGY, 2004, 122 (09) : 1348 - 1356
  • [8] Hsp27 upregulation by HIF-1 signaling offers protection against retinal ischemia in rats
    Whitlock, NA
    Agarwal, N
    Ma, JX
    Crosson, CE
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2005, 46 (03) : 1092 - 1098
  • [9] Zalewska R, 2008, MED SCI MONITOR, V14, pBR274
  • [10] Pilocarpine Protects Cobalt Chloride-induced Apoptosis of RGC-5 Cells: Involvement of Muscarinic Receptors and HIF-1α Pathway
    Zhu, Xu
    Zhou, Wei
    Cui, Yongyao
    Zhu, Liang
    Li, Juan
    Feng, Xuemei
    Shao, Biyun
    Qi, Hong
    Zheng, Jun
    Wang, Hao
    Chen, Hongzhuan
    [J]. CELLULAR AND MOLECULAR NEUROBIOLOGY, 2010, 30 (03) : 427 - 435