Total Synthesis of the Proposed Structure of Mycosporulone: Structural Revision and an Unexpected Retro-Aldol/Aldol Reaction

被引：12
|
作者：
Jung, Michael E. [1 ]
Chang, Jonah J. [1 ]
机构：
[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 18期
关键词：
METABOLITE; FUNGUS; ALDEHYDES;
D O I：
10.1021/ol302234a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The proposed structure of the fungal metabolite, mycosporulone 1, was prepared starting from the cyclohexenone ester 11 and the D-(R)-glyceraldehyde acetonide 12. The spectroscopic data for both 1 and its C2 epimer la did not match those reported for the natural product. A revised structure 29 for mycosporulone is proposed.
引用
收藏
页码：4898 / 4901
页数：4
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