New potential biologically active compounds:: Design and an efficient synthesis of N-substituted 4-aryl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-diones under microwave irradiation

被引：57
|
作者：
Tu, SJ [1 ]
Zhu, XT [1 ]
Zhang, JP [1 ]
Xu, JN [1 ]
Zhang, Y [1 ]
Wang, Q [1 ]
Jia, RH [1 ]
Jiang, B [1 ]
Zhang, JY [1 ]
Yao, CS [1 ]
机构：
[1] Xuzhou Normal Univ, Dept Chem, Key Lab Biotechnol Med Plant, Xuzhou 221009, Jiangsu, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 11期
基金：
中国国家自然科学基金;
关键词：
quinolone; microwave irradiation; potential biologically active; biomedical screening;
D O I：
10.1016/j.bmcl.2006.03.011
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of N-substituted 4-aryl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-diones were synthesized through a rapid one-pot four-component reaction under microwave irradiation. The method has the advantages of excellent yields (82-96%) and short reaction time (4-9 min). We provide new series of potential biologically active compounds for biomedical screening. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2925 / 2928
页数：4
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