Lipase catalyzed asymmetric synthesis of (R)-melonol

被引：0
|
作者：
Syam, Sujata [1 ]
Rane, Monica D. [2 ]
Bhat, Sujata V. [1 ,2 ]
机构：
[1] Indian Inst Technol, Dept Chem, Bombay 400076, Maharashtra, India
[2] Univ Bombay, VG Vaze Coll, Lab Adv Res Nat & Synth Chem, Bombay 400081, Maharashtra, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2008年 / 47卷 / 08期
关键词：
asymmetric synthesis; melonol; lipases; transesterification; hydrolysis;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Synthesis of optically pure 2,6-dimethyl-5-hepten-l-ol(melonol) has been attempted using lipases. Among three different lipases tested, pig panereatic lipase (PPL) is found to be suitable for transesterification of (+/-)-melonol to afford (R)-(+)-melonol with an enantiomeric excess of 94%.
引用
收藏
页码：1308 / 1310
页数：3
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