Cell-permeable, phosphatase-stable phosphopeptide mimetic prodrugs targeted to the SH2 domain of Stat3 inhibit invasion, growth and vasculogenic mimicry of tumor cells

被引：0
|
作者：
Mandal, Pijus K.
Liao, Warren S. -L.
Gao, Fengqin
Thudi, Nandu
Robertson, Fredika M.
Chattopadhyay, Chandrani
Ekmekcioglu, Suhendan
Ren, Zhiyong
Chen, Xiaomin
McMurray, John S.
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Biochem & Mol Biol, Houston, TX 77030 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 239卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
391-MEDI
引用
收藏
页数：1
相关论文
共 13 条
  • [1] Synthesis of Phosphatase-Stable, Cell-Permeable Peptidomimetic Prodrugs That Target the SH2 Domain of Stat3
    Mandal, Pijus K.
    Liao, Warren S-L
    McMurray, John S.
    ORGANIC LETTERS, 2009, 11 (15) : 3394 - 3397
  • [2] Inhibition of Stat3 by cell-permeable peptidomimetic prodrugs targeted to its SH2 domain
    McMurray, J. S.
    Mandal, P. K.
    Liao, W. S.
    Ren, Z.
    Chen, X.
    BIOPOLYMERS, 2007, 88 (04) : 604 - 604
  • [3] Inhibition of Stat3 by Cell-Permeable Peptidomimetic Prodrugs Targeted to its SH2 Domain
    McMurray, John S.
    Mandal, Pijus K.
    Liao, Warren S.
    Ren, Zhiyong
    Chen, Xiaomin
    PEPTIDES FOR YOUTH, 2009, 611 : 545 - 546
  • [4] PHOSPHATASE-STABLE, CELL-PERMEABLE PEPTIDOMIMETIC PRODRUGS TARGETING THE SH2 DOMAIN OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 INHIBIT TUMOR CELL PROLIFERATION IN VITRO
    Mandal, P. K.
    Liao, W.
    Rajagopal, R.
    Shanker, M.
    Scott, A. W.
    Ren, Z.
    Chen, X.
    McMurray, J. S.
    BIOPOLYMERS, 2009, 92 (04) : 346 - 346
  • [5] A cell-permeable Stat3 SH2 domain mimetic inhibitor of Stat3 activation inhibits growth of human breast tumor xenog rafts
    Zhao, Wei
    Jaganathan, Soumya
    Zhang, Xiaolei
    Turkson, James
    CANCER RESEARCH, 2011, 71
  • [6] A Cell-permeable Stat3 SH2 Domain Mimetic Inhibits Stat3 Activation and Induces Antitumor Cell Effects in Vitro
    Zhao, Wei
    Jaganathan, Soumya
    Turkson, James
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (46) : 35855 - 35865
  • [7] Targeting the SH2 domain of Stat3 with phosphopeptide mimetic prodrugs leads to tumor growth inhibition and down-regulation of phosphoTyr705 Stat3 and angiogenic pathways
    McMurray, J.
    Klostergaard, J.
    Auzenne, E. J.
    Liao, W. S. L.
    Lu, Z.
    Mandal, P. K.
    Ramesh, R.
    Shanker, M.
    Scott, A. W.
    EJC SUPPLEMENTS, 2010, 8 (07): : 134 - 134
  • [8] SH2-domain targeted Stat3 prodrugs inhibit target phosphorylation and proliferation of lung tumor cell lines
    Ramesh, Rajagopal
    Shanker, Manish
    Scott, Aileen
    Mandal, Pijus
    Liao, Warren
    Elizondo, Stephanie
    Ren, Zhiyong
    Chen, Xiaomin
    McMurray, John
    CANCER RESEARCH, 2009, 69
  • [9] Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity
    Mandal, Pijus K.
    Morlacchi, Pietro
    Knight, J. Morgan
    Link, Todd M.
    Lee, Gilbert R.
    Nurieva, Roza
    Singh, Divyendu
    Dhanik, Ankur
    Kavraki, Lydia
    Corry, David B.
    Ladbury, John E.
    McMurray, John S.
    JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (22) : 8970 - 8984
  • [10] Potent and Selective Phosphopeptide Mimetic Prodrugs Targeted to the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3
    Mandal, Pijus K.
    Gao, Fengqin
    Lu, Zhen
    Ren, Zhiyong
    Ramesh, Rajagopal
    Birtwistle, J. Sanderson
    Kaluarachchi, Kumaralal K.
    Chen, Xiaomin
    Bast, Robert C., Jr.
    Liao, Warren S.
    McMurray, John S.
    JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (10) : 3549 - 3563
12