Anterior Cingulate Cortex in Addiction: New Insights for Neuromodulation

被引:37
|
作者
Zhao, Yijie [1 ,2 ,3 ]
Sallie, Samantha N. [4 ]
Cui, Hailun [4 ]
Zeng, Ningning [5 ]
Du, Jiang [5 ]
Yuan, Tifei [5 ]
Li, Dianyou [3 ]
De Ridder, Dirk [6 ]
Zhang, Chencheng [3 ]
机构
[1] Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai, Peoples R China
[2] Fudan Univ, Minist Educ, Key Lab Computat Neurosci & Brain Inspired Intell, Shanghai, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Neurosurg,Ctr Funct Neurosurg, 197 Rui Jin Second Rd, Shanghai 200025, Peoples R China
[4] Univ Cambridge, Dept Psychiat, Addenbrookes Hosp, Level E4, Cambridge, England
[5] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China
[6] Univ Otago, Dunedin Sch Med, Sect Neurosurg, Dept Surg Sci, Dunedin, New Zealand
来源
NEUROMODULATION | 2021年 / 24卷 / 02期
关键词
Addiction; alcohol; anterior cingulate cortex; neuromodulation; substance use disorder; TRANSCRANIAL MAGNETIC STIMULATION; DORSOLATERAL PREFRONTAL CORTEX; DEEP BRAIN-STIMULATION; OBSESSIVE-COMPULSIVE DISORDER; STRIATAL DOPAMINE RELEASE; FUNCTIONAL CONNECTIVITY; SMOKING-CESSATION; NUCLEUS-ACCUMBENS; FRONTAL-CORTEX; WHITE-MATTER;
D O I
10.1111/ner.13291
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Objectives Substance use disorder (SUD) is characterized by compulsive use of addictive substances with considerable impact on both the medical system and society as a whole. The craving of substances leads to relapse in the majority of patients within one year of traditional treatments. In recent decades, neuromodulation approaches have emerged as potential novel treatments of SUD, but the ideal neural target remains contentious. Materials and Methods In this review, we discuss new insights on the anterior cingulate cortex (ACC) as a neuromodulation target for SUD. Results and Conclusion First, we illustrate that the ACC serves as a central "hub" in addiction-related neural networks of cognitive functions, including, but not limited to, decision-making, cognitive inhibition, emotion, and motivation. Then, we summarize the literature targeting the ACC to treat SUDs via available neuromodulation approaches. Finally, we propose potential directions to improve the effect of stimulating the ACC in SUD treatment. We emphasize that the ACC can be divided into at least four sub-regions, which have distinctive functions and connections. Studies focusing on these sub-regions may help to develop more precise and effective ACC stimulation according to patients' symptom profiles and cognitive deficits.
引用
收藏
页码:187 / 196
页数:10
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