Somatic Genome Editing Goes Viral

被引：1
|
作者：
Zafra, Maria Paz [1 ]
Dow, Lukas E. [1 ]
机构：
[1] Weill Cornell Med, Div Hematol & Med Oncol, Dept Med, Sandra & Edward Meyer Canc Ctr, New York, NY 10021 USA
来源：
TRENDS IN MOLECULAR MEDICINE | 2016年 / 22卷 / 10期
关键词：
CHROMOSOMAL REARRANGEMENTS; MOUSE-LIVER; CRISPR/CAS9; CANCER; CRISPR-CAS9; MICE;
D O I：
10.1016/j.molmed.2016.08.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Generating new mouse models of cancer is a challenging and laborious task that can require years of investment to interrogate a single gene. Now, Jonkers and colleagues describe the first application of CRISPR-based genome editing in the mammary gland, providing a new approach to dissect complex genetic interactions in vivo.
引用
收藏
页码：831 / 833
页数：3
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