Endogenous stromal cell-derived factor-1 (CXCL12) supports autonomous growth of acute myeloid leukemia cells

被引：16

作者：

Kim, Ha-Yon ^{[1
,3
]}

Oh, Yoon-Suk ^{[1
,3
]}

Song, Ik-Chan ^{[1
,3
]}

Kim, Seong-Woo ^{[2
]}

Lee, Hyo-Jin ^{[1
,3
]}

Yun, Hwan-Jung ^{[1
,3
]}

Kim, Samyong ^{[1
,3
]}

Jo, Deog-Yeon ^{[1
,3
]}

机构：

[1] Chungnam Natl Univ, Sch Med, Dept Internal Med, Taejon, South Korea

[2] Chungnam Natl Univ, Sch Pharm, Taejon, South Korea

[3] Daejeon Reg Canc Ctr, Taejon, South Korea

来源：

LEUKEMIA RESEARCH | 2013年 / 37卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

Acute myeloid leukemia; Apoptosis; Cell proliferation; CXCL12; CXCR4; SDF-1; CHEMOKINE RECEPTOR CXCR4; NOD/SCID MICE; TUMOR-GROWTH; SURVIVAL; EXPRESSION; VIVO; PROLIFERATION; SDF-1/CXCL12; MIGRATION; CYTOKINES;

D O I：

10.1016/j.leukres.2013.01.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the role of endogenous stromal cell-derived factor-1 (SDF-1; CXCL12) in the survival and proliferation of acute myeloid leukemia (AML) cells in vitro. CD34(+) cells from the peripheral blood of five patients with AML, as well as five AML cell lines, produced and secreted SDF-1. Knock-down of endogenous SDF-1 expression using siRNA technology downregulated the constitutive phosphorylation of SDF-1-related signaling molecules and significantly inhibited spontaneous proliferation of the AML cell lines during a 3-day incubation in serum-free conditions. These results indicate that endogenous SDF-1 expression by AML cells plays a role in the autonomous growth of the cells. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：566 / 572

页数：7

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