Levels of angiogenic factors in pregnancy and post-partum bleeding

被引：4

作者：

Eskild, Anne ^{[1
,2
,3
]}

Jeansson, Stig ^{[2
,4
]}

Jenum, Pal A. ^{[5
]}

Staff, Anne C. ^{[2
,6
]}

Thadhani, Ravi ^{[7
,8
]}

Karumanchi, Ananth ^{[7
,9
]}

Vatten, Lars J. ^{[10
]}

机构：

[1] Akershus Univ Hosp, Dept Obstet & Gynecol, N-1478 Lorenskog, Norway

[2] Univ Oslo, Fac Med, N-0316 Oslo, Norway

[3] Norwegian Inst Publ Hlth, Div Mental Hlth, Oslo, Norway

[4] Ullevaal Univ Hosp, Dept Microbiol, Oslo, Norway

[5] Asker & Baerum Hosp, Dept Microbiol, Baerum, Norway

[6] Ullevaal Univ Hosp, Dept Obstet & Gynecol, Oslo, Norway

[7] Harvard Univ, Sch Med, Boston, MA USA

[8] Massachusetts Gen Hosp, Dept Med, Renal Unit, Boston, MA 02114 USA

[9] Beth Israel Deaconess Med Ctr, Dept Med Obstet & Gynecol, Boston, MA 02215 USA

[10] Norwegian Univ Sci & Technol, Dept Publ Hlth, N-7034 Trondheim, Norway

来源：

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA | 2008年 / 87卷 / 10期

关键词：

Post-partum; bleeding; angiogenic factors; soluble fms-like tyrosine kinase-1 (sFlt-1); pregnancy;

D O I：

10.1080/00016340802415622

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

We have studied if serum levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and placenta growth factor (PlGF) in pregnancy could predict excess post-partum bleeding. In 392 normotensive singleton pregnancies, concentrations of sFlt-1 and PlGF in the first, second, and third trimester were compared between women with and without excess post-partum bleeding, defined as blood loss volume of at least 500 mL. Mean concentrations of sFlt-1 were consistently higher in all three trimesters among women who had excess post-partum bleeding compared to women without this, but significantly higher only in the second trimester. For PlGF, there were no significant differences between the groups. High concentrations of the anti-angiogenic factor sFlt-1 in maternal circulation during pregnancy may be associated with an increased risk of excess post-partum bleeding.

引用

页码：1081 / 1083

页数：3

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