Nanocarriers for siRNA delivery to overcome cancer multidrug resistance

被引：6
|
作者：
Meng QingShuo [1 ]
Yin Qi [1 ]
Li YaPing [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
来源：
CHINESE SCIENCE BULLETIN | 2013年 / 58卷 / 33期
基金：
中国国家自然科学基金;
关键词：
cationic polymers; inorganic carriers; liposomes; multidrug resistance; nanocarriers; siRNA delivery; SMALL-INTERFERING RNA; MESOPOROUS SILICA NANOPARTICLES; NONVIRAL GENE DELIVERY; POLY-L-ARGININE; IN-VIVO; CO-DELIVERY; DRUG-RESISTANCE; BREAST-CANCER; RADICAL POLYMERIZATION; TARGETED DELIVERY;
D O I：
10.1007/s11434-013-6030-9
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Multidrug resistance (MDR) is an extremely complexed phenomenon in tumor chemotherapy and is one of the major obstacles for successful treatment. Discovery of RNA interference (RNAi) offers a new strategy with great potential to reverse MDR. Specific genes, which contribute to the emerging of MDR, can be silenced by RNAi. However, many natural barriers have to be overcome for efficient and safe delivery of siRNA. In recent years, the various kinds of nanocarriers, such as liposomes, cationic polymers, and inorganic materials, have been developed to deliver siRNA and show good results in reversing MDR. This review mainly summarizes the barriers in siRNA delivery and recent progress in designing nanotechnology-based siRNA delivery systems to overcome tumor MDR.
引用
收藏
页码：4021 / 4030
页数：10
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