Efficient O-demethylation of lignin monoaromatics using the peroxygenase activity of cytochrome P450 enzymes

被引：20
|
作者：
Harlington, Alix C. [1 ]
Shearwin, Keith E. [1 ]
Bell, Stephen G. [2 ]
Whelan, Fiona [1 ]
机构：
[1] Univ Adelaide, Dept Mol & Biomed Sci, Adelaide, SA 5005, Australia
[2] Univ Adelaide, Dept Chem, Adelaide, SA 5005, Australia
来源：
CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 96期
关键词：
BIOCATALYTIC VALORIZATION; OXIDATION; ACTIVATION; CATABOLISM; PEROXIDE; ACID; P450;
D O I：
10.1039/d2cc04698a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A crucial reaction in harnessing renewable carbon from lignin is O-demethylation. We demonstrate the selective O-demethylation of syringol and guaiacol using different cytochrome P450 enzymes. These can efficiently use hydrogen peroxide which, when compared to nicotinamide cofactor-dependent monooxygenases and synthetic methods, allows for cheap and clean O-demethylation of lignin-derived aromatics.
引用
收藏
页码：13321 / 13324
页数：5
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