Regulation of cancer stem cells by p53

被引：11
|
作者：
Jerry, D. Joseph [1 ,2 ]
Tao, Luwei [1 ]
Yan, Haoheng [1 ]
机构：
[1] Univ Massachusetts, Dept Vet & Anim Sci, Amherst, MA 01003 USA
[2] Pioneer Valley Life Sci Inst, Springfield, MA 01199 USA
来源：
BREAST CANCER RESEARCH | 2008年 / 10卷 / 04期
关键词：
D O I：
10.1186/bcr2133
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The hypothesis that cancer stem cells are responsible for the chemoresistant and metastatic phenotypes of many breast cancers has gained support using cell-sorting strategies to enrich the tumor-initiating population of cells. The mechanisms regulating the cancer stem cell pool, however, are less clear. Two recent publications suggest that loss of p53 permits expansion of presumptive cancer stem cells in mouse mammary tumors and in human breast cell lines. These results add restriction of cancer stem cells as a new tumor suppressor activity attributed to p53.
引用
收藏
页数：3
相关论文
共 50 条
  • [1] Regulation of cancer stem cells by p53
    D Joseph Jerry
    Luwei Tao
    Haoheng Yan
    Breast Cancer Research, 10
  • [2] Stem cells, cancer and P53
    Salamanca-Gomez, Fabio
    GACETA MEDICA DE MEXICO, 2009, 145 (05): : 441 - 442
  • [3] Regulation of p53 in embryonic stem cells
    Solozobova, Valeriya
    Blattner, Christine
    EXPERIMENTAL CELL RESEARCH, 2010, 316 (15) : 2434 - 2446
  • [4] p53 and cancer stem cells The mevalonate connexion
    Ginestier, Christophe
    Charafe-Jauffret, Emmanuelle
    Birnbaum, Daniel
    CELL CYCLE, 2012, 11 (14) : 2583 - 2584
  • [5] Targeting cancer stem cells with p53 modulators
    Zhang, Zhan
    Liu, Ling
    Gomez-Casal, Roberto
    Wang, Xinhui
    Hayashi, Ryo
    Appella, Ettore
    Kopelovich, Levy
    DeLeo, Albert B.
    ONCOTARGET, 2016, 7 (29) : 45079 - 45093
  • [6] The ups and downs of p53 regulation in hematopoietic stem cells
    Abbas, Hussein A.
    Pant, Vinod
    Lozano, Guillermina
    CELL CYCLE, 2011, 10 (19) : 3257 - 3262
  • [7] Transcriptional regulation of cancer stem cells marker CD133 by p53
    Park, E. K.
    Bang, S. Y.
    Yi, S. A.
    Han, J. W.
    EUROPEAN JOURNAL OF CANCER, 2014, 50 : 153 - 154
  • [8] Therapeutic targeting of the p53 pathway in cancer stem cells
    Prabhu, Varun V.
    Allen, Joshua E.
    Hong, Bo
    Zhang, Shengliang
    Cheng, Hairong
    El-Deiry, Wafik S.
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2012, 16 (12) : 1161 - 1174
  • [9] p53 family members regulate cancer stem cells
    Basu, Subhasree
    Murphy, Maureen E.
    CELL CYCLE, 2016, 15 (11) : 1403 - 1404
  • [10] Regulation of p53 in normal cells and cancer cells infected with adenoviruses
    McCormick, F
    MOLECULAR MECHANISMS OF SIGNAL TRANSDUCTION, 2000, 316 : 271 - 274
12345