A Novel and Convenient Protocol for Synthesis of Pyridazines

被引：52
|
作者：
Attanasi, Orazio A. [1 ]
Favi, Gianfranco [1 ]
Filippone, Paolino [1 ]
Perrulli, Francesca R. [1 ]
Santeusanio, Stefania [1 ]
机构：
[1] Univ Urbino Carlo Bo, Ist Chim Organ, I-61029 Urbino, Italy
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 02期
关键词：
DIELS-ALDER REACTIONS; CYCLIZATION REACTIONS; GENERAL-SYNTHESIS; DERIVATIVES; GABA; AMINOPYRIDAZINES; DIHYDROCHLORIDE; CYCLOADDITION; ANTAGONIST; INHIBITORS;
D O I：
10.1021/ol802432z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new flexible strategy for the synthesis of diversely functionalized pyridazines from 4-chloro-1,2-diaza-1,3-butadienes and active methylene compounds is reported. The high chemoselectivity of this approach offers access to structural precursors of GABA-A antagonist analogues.
引用
收藏
页码：309 / 312
页数：4
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