Erythropoietin-producing tubercle granuloma in a hemodialysis patient

被引:2
|
作者
Satoh, Minoru [1 ]
Ueta, Hiroshi [1 ]
Tokura, Takehiko [1 ]
Sasaki, Tamaki [1 ]
Kashihara, Naoki [1 ]
机构
[1] Kawasaki Med Sch, Dept Hypertens & Nephrol, Kurashiki, Okayama 7010192, Japan
关键词
Erythropoietin; Tubercle granuloma; Hemodialysis; Fever of unknown etiology; In situ hybridization; GENE-EXPRESSION; POLYCYTHEMIA; ERYTHROCYTOSIS; CARCINOMA; ANEMIA; FEVER;
D O I
10.1186/1471-2369-14-91
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background: We describe a case of a fever of unknown etiology that was caused by a caseating tubercle granuloma which produced erythropoietin. To our knowledge, this is the first report of an erythropoietin-producing granuloma. Case presentation: A 48-year-old Japanese man with a 5-year history of maintenance hemodialysis for diabetic nephropathy presented with an intermittent fever over a few months. During febrile periods he developed erythema nodosum on his legs. Computed tomography showed axillary lymph node enlargement and this was further corroborated by a gallium scan that revealed high gallium uptake in these nodes. A Mantoux test was positive and an interferongamma release assay for tuberculosis diagnosis was also positive. Lymph node tuberculosis was suspected and the patient underwent lymphadenectomy. Histological analysis of the lymph nodes revealed a caseating granuloma that showed positive results on an acid-fast bacteria stain and a Mycobacterium tuberculosis polymerase chain reaction test. After lymphadenectomy, however, the patient's hemoglobin levels rapidly decreased from 144 to 105 g/L, and this was further compounded by a decrease in serum erythropoietin from 223 mlU/mL to 10.7 mlU/mL by postoperative day 21. We suspected the tubercle to be a source of the erythropoietin and this was further confirmed by in situ hybridization. Conclusions: We report for the first time ectopic erythropoietin production by a tuberculous lymph node. Our observations are substantiated by a postoperative decline in his erythropoietin level and a clinical requirement for erythropoietin treatment.
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页数:5
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