Trichloroisocyanuric acid-mediated one-pot synthesis of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles at ambient temperature

被引：30
|
作者：
Pore, D. M. [1 ]
Mahadik, S. M. [1 ]
Desai, U. V. [1 ]
机构：
[1] Shivaji Univ, Dept Chem, Kolhapur 416004, Maharashtra, India
来源：
SYNTHETIC COMMUNICATIONS | 2008年 / 38卷 / 18期
关键词：
acylhydrazines; acylhydrazones; oxidative cyclization; 1,3,4-oxadiazoles; trichloroisocyanuric acid;
D O I：
10.1080/00397910802054289
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method for the one-pot synthesis of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles has been developed using trichloroisocyanuric acid (TCCA) at ambient temperature. A wide variety of aromatic as well as heterocyclic aldehydes exhibit condensation with a variety of acylhydrazines followed by oxidative cyclization to yield corresponding unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles. The mild nature of the synthesis and short reaction time are notable advantages of the developed protocol.
引用
收藏
页码：3121 / 3128
页数：8
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