Fragment-to-Lead Medicinal Chemistry Publications in 2015

被引：52

作者：

Johnson, Christopher N. ^{[1
]}

Erlanson, Daniel A. ^{[2
]}

Murray, Christopher W. ^{[1
]}

Rees, David C. ^{[1
]}

机构：

[1] Astex Pharmaceut, 436 Cambridge Sci Pk,Milton Rd, Cambridge CB4 0QA, England

[2] Carmot Therapeut Inc, 409 Illinois St, San Francisco, CA 94158 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2017年 / 60卷 / 01期

关键词：

STRUCTURE-BASED DESIGN; ATAD2 BROMODOMAIN INHIBITORS; PROTEIN-PROTEIN INTERACTIONS; SMALL-MOLECULE INHIBITORS; LEUCINE-ZIPPER KINASE; DRUG DISCOVERY; PARALLEL SYNTHESIS; POTENT; IDENTIFICATION; OPTIMIZATION;

D O I：

10.1021/acs.jmedchem.6b01123

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Fragment-based drug discovery (FBDD) is now well-established as a technology for generating new chemical leads and drags. This. Miniperspective provides a tabulated overview of the fragment-to-lead literature published in the year 2015, together with a commentary on trends observed across the FBDD field during this time. It is hoped that this tabulated summary will provide a useful point of reference for both FBDD practitioners and the wider medicinal Chemistry community.

引用

页码：89 / 99

页数：11

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