Three minor new compounds from the aerial parts of Leonurus japonicus

被引：19

作者：

Zhong, Wei-Mao ^{[1
,5
]}

Cui, Zhao-Meng ^{[2
,3
]}

Liu, Zhi-Ke ^{[1
,5
]}

Yang, Yan ^{[1
]}

Wu, Da-Rong ^{[4
]}

Liu, Shao-Hua ^{[4
]}

Long, Hui ^{[1
,5
]}

Sun, Han-Dong ^{[1
]}

Dang, Yong-Jun ^{[2
,3
]}

Xiao, Wei-Lie ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Minist Educ, Key Lab Mol Med, Shanghai 200032, Peoples R China

[3] Fudan Univ, Shanghai Med Coll, Dept Biochem & Mol Biol, Shanghai 200032, Peoples R China

[4] Chengdu Pharmaceut Grp Co Ltd, Chengdu 610031, Peoples R China

[5] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2015年 / 26卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Leonurus japonicus; Diterpenoid; Ionone derivative; Jurkat IL2 secretion; LABDANE-TYPE DITERPENOIDS;

D O I：

10.1016/j.cclet.2015.05.004

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Phytochemical investigation of the aerial parts of Leonurus japonicus led to the isolation of one new labdane diterpenoid, leojaponin D (1) and two new ionone derivatives, leojaponones A and B (2 and 3), together with seven known diterpenoids (4-10). Their structures were elucidated by extensive 1D and 2D NMR spectroscopic data and by comparison with data reported in the literature. Selected isolates were evaluated their effects on Jurkat IL2 secretion. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：1000 / 1003

页数：4

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