A polymorphism in human CD1A is associated with susceptibility to tuberculosis

被引：26
|
作者：
Seshadri, C. [1 ]
Thuong, N. T. T. [2 ]
Yen, N. T. B. [3 ]
Bang, N. D. [3 ]
Chau, T. T. H. [4 ]
Thwaites, G. E. [2 ,5 ]
Dunstan, S. J. [2 ,5 ]
Hawn, T. R. [1 ]
机构：
[1] Univ Washington, Div Allergy & Infect Dis, Dept Med, Seattle, WA 98109 USA
[2] Hosp Trop Dis, Oxford Univ Clin Res Unit, Ho Chi Minh City, Vietnam
[3] Pham Ngoc Thach Hosp TB & Lung Dis, Ho Chi Minh City, Vietnam
[4] Hosp Trop Dis, Ho Chi Minh City, Vietnam
[5] Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford, England
来源：
GENES AND IMMUNITY | 2014年 / 15卷 / 03期
基金：
英国惠康基金;
关键词：
human; tuberculosis; host response; CD1A; genetic association; single-nucleotide polymorphism; LIPID ANTIGEN; RECOGNITION; IMMUNITY; COMMON;
D O I：
10.1038/gene.2014.5
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
CD1 proteins are antigen-presenting molecules that evolved to present lipids rather than peptides to T cells. However, unlike major histocompatibility complex genes, CD1 genes show low rates of polymorphism and have not been clearly associated with human disease. We report that an intronic polymorphism in CD1A (rs411089) is associated with susceptibility to tuberculosis in two cohorts of Vietnamese adults (combined cohort odds ratio 1.78; 95% confidence interval: 1.24-2.57; P=0.001). These data strengthen the hypothesis that CD1A-mediated lipid antigen presentation is important for controlling tuberculosis in humans.
引用
收藏
页码：195 / 198
页数：4
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