Palatability Can Drive Feeding Independent of AgRP Neurons

被引：115

作者：

Denis, Raphael G. P. ^{[1
]}

Joly-Amado, Aurelie ^{[1
]}

Webber, Emily ^{[11
,12
]}

Langlet, Fanny ^{[5
,6
]}

Schaeffer, Marie ^{[2
,3
,4
]}

Padilla, Stephanie L. ^{[9
,10
]}

Cansell, Celine ^{[1
]}

Dehouck, Benedicte ^{[5
,6
]}

Castel, Julien ^{[1
]}

Delbes, Anne-Sophie ^{[1
]}

Martinez, Sarah ^{[1
]}

Lacombe, Amelie ^{[1
]}

Rouch, Claude ^{[1
]}

Kassis, Nadim ^{[1
]}

Fehrentz, Jean-Alain ^{[7
]}

Martinez, Jean ^{[7
]}

Verdie, Pascal ^{[7
]}

Hnasko, Thomas S. ^{[8
]}

Palmiter, Richard D. ^{[9
,10
]}

Krashes, Michael J. ^{[11
,12
]}

Gueler, Ali D. ^{[9
,10
]}

Magnan, Christophe ^{[1
]}

Luquet, Serge ^{[1
]}

机构：

[1] Univ Paris Diderot, CNRS, Unite Mixte Rech 8251, Unite Biol Fonct & Adaptat,Sorbonne Paris Cite, F-75205 Paris, France

[2] Inst Genom Fonct, CNRS, Unite Mixte Rech 5203, F-34000 Montpellier, France

[3] INSERM, U661, F-34000 Montpellier, France

[4] Univ Montpellier, Unite Mixte Rech 5203, F-34000 Montpellier, France

[5] Jean Pierre Aubert Res Ctr, INSERM, F-59000 Lille, France

[6] Univ Droit & Sante Lille, Fac Med, F-59000 Lille, France

[7] Univ Montpellier, Ecole Natl Super Chim Montpellier, CNRS, Inst Biomol Max Mousseron,Unite Mixte Rech 5247, F-34093 Montpellier 5, France

[8] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92093 USA

[9] Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA

[10] Univ Washington, Dept Biochem, Seattle, WA 98195 USA

[11] NIDDK, Diabet Endocrinol & Obes Branch, NIH, Bethesda, MD 20892 USA

[12] NIDA, Baltimore, MD 21224 USA

来源：

CELL METABOLISM | 2015年 / 22卷 / 04期

关键词：

CAUSES GHRELIN RESISTANCE; FOOD-INTAKE; NPY/AGRP NEURONS; BODY-WEIGHT; DOPAMINE; NUCLEUS; LEPTIN; EXPRESSION; REWARD; MICE;

D O I：

10.1016/j.cmet.2015.07.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Feeding behavior is exquisitely regulated by homeostatic and hedonic neural substrates that integrate energy demand as well as the reinforcing and rewarding aspects of food. Understanding the net contribution of homeostatic and reward-driven feeding has become critical because of the ubiquitous source of energy-dense foods and the consequent obesity epidemic. Hypothalamic agouti-related peptide-secreting neurons (AgRP neurons) provide the primary orexigenic drive of homeostatic feeding. Using models of neuronal inhibition or ablation, we demonstrate that the feeding response to a fast ghrelin or serotonin receptor agonist relies on AgRP neurons. However, when palatable food is provided, AgRP neurons are dispensable for an appropriate feeding response. In addition, AgRP-ablated mice present exacerbated stress-induced anorexia and palatable food intake-a hallmark of comfort feeding. These results suggest that, when AgRP neuron activity is impaired, neural circuits sensitive to emotion and stress are engaged and modulated by food palatability and dopamine signaling.

引用

页码：646 / 657

页数：12

共 51 条

[1] Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite [J].