Placental Mesenchymal Stem Cells: A Unique Source for Cellular Cardiomyoplasty

被引：16
|
作者：
Makhoul, Georges
Chiu, Ray C. J.
Cecere, Renzo
机构：
[1] McGill Univ, Ctr Hlth, Div Cardiac Surg, Montreal, PQ H3A 1A1, Canada
[2] McGill Univ, Ctr Hlth, Div Expt Surg, Montreal, PQ H3A 1A1, Canada
来源：
ANNALS OF THORACIC SURGERY | 2013年 / 95卷 / 05期
关键词：
HUMAN AMNIOTIC MEMBRANE; UMBILICAL-CORD BLOOD; HUMAN BONE-MARROW; IN-VITRO DIFFERENTIATION; TERM PLACENTA; STROMAL CELLS; MULTIPOTENT CELLS; EPITHELIAL-CELLS; FETAL MEMBRANES; ADHERENT CELLS;
D O I：
10.1016/j.athoracsur.2012.11.053
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In coronary heart disease, the use of stem cells for regeneration purposes has been broadly studied. Whereas bone marrow mesenchymal stem cells remain the most extensively investigated, other cell sources have been reported. Here we discuss and compare the characteristics of placenta-derived mesenchymal stem cells as a novel alternative cell source for cellular cardiomyoplasty. These cells are isolated from the human term placenta, which is normally discarded post partum. With their lack of ethical conflicts and young age, the readily available placenta-derived mesenchymal stem cells could be more suitable for myocardial regenerative therapy. (C) 2013 by The Society of Thoracic Surgeons
引用
收藏
页码：1827 / 1833
页数：7
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