Differential effects of nitric oxide synthase inhibitor, 7-nitroindazole, on discriminative stimulus and somatic effects of naloxone in morphine-dependent rats

被引：9
|
作者：
Medvedev, IO [1 ]
Dravolina, OA [1 ]
Bespalov, AY [1 ]
机构：
[1] Pavlov Med Univ, Valdman Inst Pharmacol, Lab Behav Pharmacol, St Petersburg 197089, Russia
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1999年 / 377卷 / 2-3期
关键词：
naloxone; morphine withdrawal; nitric oxide (NO) synthase inhibitor; drug discrimination; Y-maze; (rat);
D O I：
10.1016/S0014-2999(99)00435-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Our previous report suggested that antagonists acting at NMDA receptors attenuate discriminative stimulus effects of naloxone in morphine dependent rats. Nitric oxide (NO) is a putative second messenger which mediates NMDA receptor activation. The present study evaluated behavioral effects of NO synthase inhibitor, 7-nitroindazole in morphine-dependent rats trained to discriminate 0.1 mg/kg naloxone from saline. 7-Nitroindazole did not significantly affect naloxone's discriminative stimulus effects but decreased naloxone-induced weight loss and abolished expression of several withdrawal signs - diarrhea, scream on touch, tremor and 'wet dog'-like shaking suggesting different mechanisms for subjective and somatic components of opioid withdrawal. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：183 / 186
页数：4
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