The Vaporization Enthalpies and Vapor Pressures of Some Primary Amines of Pharmaceutical Importance by Correlation Gas Chromatography

Vapor pressures, vaporization, and sublimation enthalpies of several pharmaceuticals have been evaluated by a combination of correlation chromatography experiments, differential calorimetry measurements with existing literature values. The compounds investigated and their properties include 1-adamantylamine [Delta cr(l)H(m)(T-fus)/kJ center dot mol(-1) = (7.3 +/- 0.2); T-fus/K = (477.4 +/- 0.9); Delta H-g(1)m(298.15 K)/kJ center dot mol(-1) = (59.9 +/- 2.5); Delta H-g(cr)m(298.15 K)/kJ center dot mo(l-)1 = (59.9 +/- 3.5); p((l))/Pa = (21 +/- 1); p(cr)/Pa = (11.5 +/- 2.1)]; 1-adamantyl-ethanamine, [Delta H-g(1)m(298.15 K)/kJ center dot mol(-1) = (68.7 +/- 3.7); p((l))/Pa = (3 +/- 1)]; alpha,alpha-dimethylphenethylamine [Delta l(g)H(m)(298.15 K)/kJ center dot mol(-1) = (60.2 +/- 2.6); p((l))/Pa = (35 +/- 4)]; trans 2-phenylcyclopropylamine [Delta l(g)H(m)(298.15 K)/kJ center dot mol(-1) = (60.3 +/- 2.1), p((l))/Pa = (28 +/- 5)]; 1-dodecanamine [Delta cr(g)H(m)(298.15 K)/kJ center dot mol(-1) = (118.3 +/- 1.8); p((cr))/Pa = 1.6 +/- 0.1]; and 1-tetradecanamine [Delta cr(g)H(m)(298.15 K)/kJ center dot mol(-1) = (134.5 +/- 2.1); p((cr))/Pa = 0.12 +/- 0.04]. Vapor pressure equations also derived from vapor pressureretention time correlations as a function of temperature are reported for both standards and targets. The equations appear applicable from T/K = 298.15 to each compounds respective boiling temperature.