Outcomes inN3Head and Neck Squamous Cell Carcinoma and Role of Upfront Neck Dissection

被引：7
|
作者：
Boros, Angela [1 ]
Blanchard, Pierre [1 ,2 ]
Dade, Arlette [3 ]
Gorphe, Philippe [3 ]
Breuskin, Ingrid [3 ]
Even, Caroline [3 ]
Nguyen, France [1 ]
Deutsch, Eric [1 ,2 ,4 ]
Bidault, Francois [5 ]
Janot, Francois [3 ]
Temam, Stephane [3 ]
Mirghani, Haitham [3 ]
Tao, Yungan [1 ,2 ,4 ]
机构：
[1] Gustave Roussy Canc Campus, Dept Radiat Oncol, 114 Rue Edouard Vaillant, F-94805 Villejuif, France
[2] Univ Paris Sud, Le Kremlin Bicetre, France
[3] Gustave Roussy Canc Campus, Dept Head & Neck Oncol, Villejuif, France
[4] INSERM 1030 Mol Radiotherapy, Villejuif, France
[5] Gustave Roussy Canc Campus, Dept Radiol, Villejuif, France
来源：
LARYNGOSCOPE | 2021年 / 131卷 / 03期
关键词：
Head and neck cancer; N3; neck dissection; chemoradiotherapy; CONCOMITANT CHEMOTHERAPY; ADVANCED HEAD; CANCER; RADIOTHERAPY; CHEMORADIOTHERAPY; N3;
D O I：
10.1002/lary.28893
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objectives We investigated the prognostic factor of N3 head and neck squamous cell carcinoma (HNSCC), including the role of upfront neck dissection (UFND) before radiotherapy (RT). Methods We retrospectively reviewed the charts of consecutive N3 HNSCC patients treated with curative intent RT. Results In the study, 323 N3 HNSCC patients were included. Of those, 125 patients (39%) had UFND. Median follow-up was 3.9 years (0-14.8 years). Overall survival (OS) at 5 years was 31.2%, and progression-free survival (PFS) was 26%. In the multivariate analysis, OS was improved in PS 0, T1-2 tumors, patients receiving concurrent chemotherapy, never or former smokers, and UFND. UFND was strongly associated with increased OS (45.7% vs. 21.2%,P < .001), and PFS (P < .001). Regardless of neck node size, UFND improved survival (P= .001 for <= 7 cm andP= .004 for > 7 cm). Conclusion UFND could improve treatment outcomes in N3 HNSCC, especially for non-oropharyngeal cancer, regardless of neck node size. Level of Evidence 2BLaryngoscope, 2020
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收藏
页码：E844 / E850
页数：7
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