DBU-promoted cyclization of vinyl isocyanides with ethers via the functionalization of a C(sp3)-H bond for the synthesis of isoquinolines

被引：19
|
作者：
Qian, Ping [1 ]
Du, Bingnan [1 ]
Zhou, Jie [1 ]
Mei, Haibo [1 ]
Han, Jianlin [1 ]
Pan, Yi [1 ,2 ]
机构：
[1] Nanjing Univ, Sch Chem & Chem Engn, Nanjing 210093, Jiangsu, Peoples R China
[2] Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 210093, Jiangsu, Peoples R China
来源：
RSC ADVANCES | 2015年 / 5卷 / 80期
基金：
中国国家自然科学基金;
关键词：
C-H BONDS; FREE OXIDATIVE FUNCTIONALIZATION; METAL-FREE; COUPLING REACTION; RADICAL TRIFLUOROMETHYLATION; ACTIVATED ALKENES; 2-ISOCYANOBIPHENYLS; ADJACENT; PHENANTHRIDINES; NITROGEN;
D O I：
10.1039/c5ra11530b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A DBU-promoted cascade functionalization of a C(sp(3))-H bond adjacent to oxygen and a radical cyclization reaction of vinyl isocyanides were developed. The reaction was carried out without the use of any metal catalysts or photoredox catalysis, which provides easy access to multi-functionalized isoquinolines.
引用
收藏
页码：64961 / 64965
页数：5
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