S-adenosyl-L-methionine prevents 5-HT1A receptors up-regulation induced by acute imipramine in the frontal cortex of the rat

被引：5

作者：

Bellido, I ^{[1
]}

Gomez-Luque, A

Plaza, A

Rius, F

Ortiz, P

de la Cuesta, FS

机构：

[1] Univ Malaga, Sch Med, Dept Pharmacol & Clin Therapeut, Malaga, Spain

[2] Carlos Haya Hosp, Dept Psychiat, Malaga, Spain

[3] Univ Malaga, Sch Med, Dept Stat, Malaga, Spain

来源：

NEUROSCIENCE LETTERS | 2002年 / 321卷 / 1-2期

关键词：

imipramine; S-adenosyl-L-methionine; serotonin(1A); frontal cortex; hippocampus; forced swim test;

D O I：

10.1016/S0304-3940(02)00044-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

S-adenosyl-L-methionine (SAM) has shown efficacy in speeding the onset of the antidepressant effect of imipramine in depressed patients. This effect may be related to their interactions at the serotonin(1A) (5-HT1A) receptors. Acute imipramine up-regulated the frontal cortex 5-HT1A receptors (B-max, 51.5 +/- 8.4 fmol/mg protein) vs. saline (B-max, 27.5 +/- 5.9 fmol/ mg protein), and did not show antidepressant effect. Acute SAM and imipramine + SAM did not modify frontal cortex 5HT(1A) receptors, and showed antidepressant effects (decrease of the immobility response of 26%, P < 0.01; and 47%, P < 0.001) vs. saline. All the chronic treatments showed antidepressant effects and up-regulated the hippocampus 5HT1A receptors. SAM prevents the 5-HT1A receptor up-regulation induced by acute imipramine in the frontal cortex. This mechanism may contribute to imipramine's antidepressant effect. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：110 / 114

页数：5

共 37 条

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