Synthesis of branched PEG brushes hybrid hydrophilic magnetic nanoparticles for the selective enrichment of N-linked glycopeptides

被引：98

作者：

Xiong, Zhichao ^{[1
,2
]}

Zhao, Liang ^{[1
]}

Wang, Fangjun ^{[1
]}

Zhu, Jun ^{[1
]}

Qin, Hongqiang ^{[1
]}

Wu, Ren'an ^{[1
]}

Zhang, Weibing ^{[1
,2
]}

Zou, Hanfa ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China

[2] E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 20023, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 65期

关键词：

IRON-OXIDE NANOPARTICLES; FACILE SYNTHESIS; GLYCOSYLATION HETEROGENEITY; INTERACTION CHROMATOGRAPHY; MASS-SPECTROMETRY; SEPARATION; MICROSPHERES; FUNCTIONALIZATION; PHOSPHOPEPTIDES; GLYCOPROTEINS;

D O I：

10.1039/c2cc33600f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hybrid Fe3O4@SiO2@PEG-Maltose MNPs were synthesized by SI-ATRP of branched PEG brushes on the surface and subsequent functionalization with hydrophilic maltose group, and the multifunctional materials were utilized for selective enrichment of N-linked glycopeptides from biological samples with high specifity, high sensitivity, and large binding capacity.

引用

页码：8138 / 8140

页数：3

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