PREVENTION OF OBSTETRIC COMPLICATIONS ASSOCIATED WITH THROMBOPHILIA GENE POLYMORPHISMS

被引：0
|
作者：
Shifman, E. M. [1 ]
Barinov, S., V [2 ]
Dolgikh, V. T. [2 ]
Medyannikova, I., V [2 ]
Blauman, S., I [3 ]
机构：
[1] Russian Univ Peoples Friendship, Moscow 117198, Russia
[2] Omsk State Med Acad, Omsk 644043, Russia
[3] Clin Matern Hosp 6, Omsk 644112, Russia
来源：
GEMATOLOGIYA I TRANSFUZIOLOGIYA | 2015年 / 60卷 / 01期
关键词：
obstetrical complications; hemostasis; thrombophilia gene polymorphisms; thromboelastography; REFERENCE RANGES; HEMORRHAGE; TESTS;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The structure of thrombophilia gene polymorphisms and disorders in the haemostasis are studied in 343 patients with obstetrical complications (main group) during the third trimester of the pregnancy. We revealed an important contribution of MTHFR gene allele variant 677T and of PA1-1 gene 4G/5G polymorphism to the development of preeclampsia.Thromboelastography is recommended for the diagnosis of gestation coagulopathy in patients with obstetrical complications with changes in the haemostatic tests. The urgency of correction of disorders of haemostasis is determined by the parameters of the clot formation (sensitivity 80%, specificity 82%). Correction of the disorders of haemostasis is indicated for pregnant patients with thrombophilia gene polymorphisms, who develop obstetrical disorders: low-molecular heparin and/or acetylsalicylic acid with folic acid and group B vitamins.
引用
收藏
页码：24 / 28
页数：5
相关论文
共 50 条
  • [1] Congenital Thrombophilia Associated to Obstetric Complications
    Cynthia Villarreal
    Gerardo García-Aguirre
    Carmen Hernández
    Olynka Vega
    José R. Borbolla
    María T. Collados
    Journal of Thrombosis and Thrombolysis, 2002, 14 : 163 - 169
  • [2] Congenital thrombophilia associated to obstetric complications
    Villarreal, C
    Garcia-Aguirre, G
    Hernández, C
    Vega, O
    Borbolla, JR
    Collados, MT
    JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 2002, 14 (02) : 163 - 169
  • [3] Thrombophilia and obstetric complications
    Makatsaria, AD
    Bitsadze, VO
    THROMBOSIS RESEARCH, 2005, 115 : 128 - 128
  • [4] Thrombophilia carriers predisposed to obstetric complications
    Morris, K
    LANCET, 1999, 353 (9148): : 214 - 214
  • [5] LMWH and micronized progesterone in the prevention of repeated obstetric complications in patients with multiple pregnancy and thrombophilia
    Bitsadze, Viktoriya
    Makatsariya, Natalya
    Khizroeva, Dzhamilya
    THROMBOSIS RESEARCH, 2012, 130 : S157 - S158
  • [6] Pregnancy management in women with history of obstetric complications and thrombophilia
    Makatsariya, A. D.
    Bitsadze, V. O.
    Baimuradova, S. M.
    Akinshina, S., V
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2009, 7 : 440 - 440
  • [7] AKT1 Gene Polymorphisms and Obstetric Complications in the Patients with Schizophrenia
    Joo, Eun-Jeong
    Lee, Kyu-Young
    Jeong, Seong-Hoon
    Roh, Myoung-Sun
    Kim, Se Hyun
    Ahn, Yong-Min
    Kim, Yong Sik
    PSYCHIATRY INVESTIGATION, 2009, 6 (02) : 102 - 107
  • [8] Metabolic syndrome and thrombophilia as the risk factor for obstetric complications.
    Pshenichnikova, E.
    Pshenichnikova, T.
    Makatsaria, A.
    HYPERTENSION IN PREGNANCY, 2006, 25 : 63 - 63
  • [9] Prevention of recurrent thromboembolic complications in women with thrombophilia
    Akinshina, S. V.
    Bitsadze, V. O.
    Baimuradova, S. M.
    Makatsaria, A. D.
    THROMBOSIS RESEARCH, 2011, 127 : S148 - S148
  • [10] Prevention of recurrent pregnancy complications in patients with thrombophilia
    Makatsariya, A. D.
    Bitsadze, V. O.
    Baimuradova, S. M.
    Perederyeva, E. B.
    Pshenichnikova, T. B.
    Akinshina, S. V.
    THROMBOSIS RESEARCH, 2007, 119 : S111 - S111
12345