Live Salmonella enterica serovar Typhimurium (S. Typhimurium) elicit dendritic cell responses that differ from those induced by killed S. Typhimurium

被引：21
|
作者：
Norimatsu, M [1 ]
Chance, V
Dougan, G
Howard, CJ
Villarreal-Ramos, B
机构：
[1] Inst Anim Hlth, Newbury RG20 7NN, Berks, England
[2] Univ London Imperial Coll Sci Technol & Med, Ctr Mol Microbiol & Infect, Dept Biol Sci, London SW7 2AZ, England
来源：
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2004年 / 98卷 / 3-4期
基金：
英国生物技术与生命科学研究理事会;
关键词：
salmonella typhimurium; bovine; dendritic cells; killed; live;
D O I：
10.1016/j.vetimm.2003.12.008
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The immune response of bovine monocytes-derived dendritic cells (DC) exposed to either live or killed Salmonella enterica serovar Typhimurium was compared. Both live and killed bacteria induced changes in morphology with distinctive formation of processes and up-regulation of the ability of DC to stimulate allogeneic T-cell proliferation. Also, both live and killed bacteria up-regulated the expression of MHC-I, MHC-II and CD80. However, live bacteria induced greater up-regulation of the expression of CD40 and CD86 than killed bacteria. Live bacteria also induced greater up-regulation of transcription for IL-6, IL-12 and GM-CSF than killed bacteria as measured by quantitative RT-PCR. These data suggest that blood-monocyte-derived DC may follow distinct maturation pathways following exposure to live or killed bacteria. These differences are likely to have consequences for the priming of the adaptive immune responses. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：193 / 201
页数：9
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