Cocaine withdrawal in Planaria

被引：55
|
作者：
Raffa, RB
Valdez, JM
机构：
[1] Temple Univ, Sch Pharm, Dept Pharmaceut Sci, Philadelphia, PA 19140 USA
[2] Temple Univ, Sch Med, Dept Pharmacol, Philadelphia, PA 19140 USA
[3] Temple Univ, TMARC Program, Philadelphia, PA 19140 USA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2001年 / 430卷 / 01期
关键词：
cocaine; Planaria; UV light;
D O I：
10.1016/S0014-2999(01)01358-9
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cocaine-exposed planarians displayed abstinence-induced withdrawal behavior when placed into cocaine-free, but not cocaine-containing, water. The effect, manifested and quantified using a new spontaneous locomotor velocity metric, was dose-dependently related to cocaine exposure (8 x 10(-9) to 8 x 10(-5) M). Ultraviolet light (254 nm = 7.83 x 10(-19) J), which was previously shown to interfere with drug-receptor interactions in Planaria, enhanced the abstinence-induced decreased locomotor velocity. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：143 / 145
页数：3
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