Regioselective synthesis of trifluoromethylated 3-(pyrazolyl)indoles on the basis of 6-(trifluoromethyl)comanic acid

被引：30
|
作者：
Usachev, Boris I. [1 ]
Obydennov, Dmitrii L. [1 ]
Sosnovskikh, Vyacheslav Ya. [1 ]
机构：
[1] Ural Fed Univ, Dept Chem, Ekaterinburg 620083, Russia
来源：
JOURNAL OF FLUORINE CHEMISTRY | 2012年 / 135卷
关键词：
6-(Trifluoromethyl)comanic acid; 3-(Pyrazolyl)indoles; Trifluoromethylated heterocycles; Fischer reaction; Regioselectivity; PALLADIUM-CATALYZED ANNULATION; INDOLE-DERIVATIVES; AROMATIC-COMPOUNDS; ANTIFUNGAL; ENAMINES;
D O I：
10.1016/j.jfluchem.2011.12.008
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A number of trifluoromethylated 3-(pyrazolyl)indoles was synthesized from 2-(trifluoromethyl)comanic acid, its ethyl ester and amide via intermediate isomeric 5(3)-[3,3,3-trifluoro-2-(phenylhydrazono)-propyl]pyrazole-3(5)-carboxylic acids and their derivatives. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：278 / 284
页数：7
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